摘要
目的探讨基底细胞样乳腺癌中E-cadherin的表达及其临床意义。方法应用免疫组化方法检测42例经病理学证实为基底细胞样乳腺癌患者的乳腺癌组织、癌旁组织及周围正常乳腺组织中E-cadherin的表达。结果 E-cadherin在基底细胞样乳腺癌中表达明显低于癌旁及周围正常乳腺组织(P<0.05);E-cad-herin在不同组织分化程度及淋巴结转移的基底细胞样乳腺癌中的表达差异有统计学意义(P<0.05),但在不同临床分期、年龄和肿瘤大小之间差异无统计学意义。结论 E-cadherin的表达可作为基底细胞样乳腺癌恶性程度和预后判断的重要指标。
Objective To investigate the expression of tumor suppressor gene E-cadherin in female basal like breast carcinoma.Methods The expression of E-cadherin gene in 42 cases of basal-like breast carcinoma and normal tissue of adjacent to cancer and normal breast tissue were detected Using immunohistochemical staining method.Results E-cadherin expression was lower in the basal-like breast carcinoma samples than that in normal breast tissue and normal tissue of adjacent to cancer.E-cadherin expression was significantly associated with the differentiations and lymph node metastasis,resepectively(P < 0.05).E-cadherin expression had no statistical significant difference in different clinical TNM stages,age and tumor size(P > 0.05).Conclusion The examination of E-cadherin expression can be used as a vital index to evaluate the biological behavior and prognosis of breast carcinoma.
出处
《宁夏医科大学学报》
2012年第3期257-259,318,共4页
Journal of Ningxia Medical University
