摘要
目的观察舒利迭[沙美特罗/替卡松粉吸入剂(50μg/500μg)]在对慢性阻塞性肺疾病(COPD)急性加重期治疗的过程中对全身炎症标记物的影响。方法 COPD加重期患者60例为研究对象。30例健康查体者作为对照组。患者入院当天检测血C反应蛋白(CRP)、血清前清蛋白(PA)、可溶性细胞间黏附分子-1(sICAM-1)、白细胞介素(IL-6)、IL-8、肿瘤坏死因子-α(TNF-α)等指标,COPD患者经舒利迭治疗4周后再复查上述指标。结果急性加重期COPD患者治疗前血清CRP和PA浓度在治疗前后比较差异有统计学意义(P<0.05)。同时,治疗前后sICAM-1比较差异有统计学意义(P<0.05)。IL-6、IL-8、TNF-α水平在治疗后明显低于治疗前,差异有统计学意义(P<0.05)。结论以上炎症因子在一定程度上反映了COPD患者的病情轻重,同时通过吸入舒利迭可以有效地控制COPD患者气道炎症,对临床治疗有重要意义。
Objective To explore the influence of seretide on systemic inflammatory markers in the treatment of acute exacerbation of chronic obstructive pulmonary disease（AECOPD）.Methods 60 patients with AECOPD were selected in the study.30 healthy ones were as control group.Serum levels of C-reactive protein（CRP）,prealbumin（PA）,soluble intercellular adhesion molecule-1（sICAM-1） and cytokines were detected on admission.According to the classification criteria of COPD,the patients were divided into three groups.The above indexes were redetected after 4-week seretide treatment.The serum levels of cytokines were measured by radioimmunoassay（RIA）.Results The levels of CRP and PA in the AECOPD group had significant differences before and after treatment（P0.05）.At the same time,the sICAM-1 level showed statistical difference before and after treatment（P0.05）.The levels of IL-6,IL-8 and TNF-α after treatment were significantly lower than before treatment with statistical difference（P0.05）.Conclusion The above inflammatory markers reflect the severity of disease condition to some degree in COPD.Seretide inhalation can effectively control airway inflammation in COPD patients with important significance to clinical treatment.
出处
《检验医学与临床》
CAS
2012年第1期16-17,19,共3页
Laboratory Medicine and Clinic
