摘要
目的通过对类风湿关节炎(RA)患者血清中白细胞介素23(IL-23)水平的检测,研究其与RA疾病活动的相关性。方法用酶联免疫吸附法(ELISA)检测59例RA患者和30例健康对照者的血清IL-23水平,分析RA患者与健康对照者的IL-23水平的差异;检测RA患者疾病活动性、临床指标、骨破坏情况,探讨其与IL-23水平相关性。结果 RA组血清IL-23浓度高于健康对照组,差异有统计学意义(P<0.01)。RA组血清IL-23水平与C反应蛋白、疾病活动性积分(DAS28)呈正相关(r值分别为0.481、0.461;P均<0.05)。RA组患者不同X线分期IL-23水平存在明显差异(P<0.05)。结论 RA患者血清IL-23的水平比健康人升高;血清IL-23水平可作为RA活动性参考指标;IL-23参与RA的发病过程尤其是骨破坏机制。
Objective Through the detection of serum Interleukin-23 (IL-23) levels of rheumatoid arthritis (RA) patients, to study the correlation between it and RA activity. Methods Serum samples from 59 patients with RA and 30 healthy controls were obtained. The chnical parameters of disease activity were assessed including the 28-joint disease activity score (DAS28), C-reactive protein (CRP) levels, rheumatoid factors (RF), and the degree of bony erosions determined by X-rays. IL-23 were measured by enzyme-linked immunosorbent assay(ELISA) .The correlation between serum levels of IL-23 and clinical features of patients with RA were analyzed. Results ( 1 )The level of serum IL-23 in RA patients were significantly elevated in patients with RA compared to that of healthy controls. (2)Serum IL-23 levels in RA was correlated with CRP, DAS 28 score (3)The levels of IL-23 of X-rays classification phase I, II ,III and IV in RA group were significandy gradually elevated in RA patients. Conclusion The levels of serum IL-23 in RA patients were higher than that of the normal controis. The elevated serum IL-23 levels might be the useful markers for active RA. In addition, IL-23 was involved in disease progression and bony erosion of RA.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
2012年第1期59-61,共3页
Journal of China Medical University
基金
国家自然科学基金资助项目(81072450)