摘要
淋球菌和沙眼衣原体的耐药在临床多见。淋球菌的耐药不仅可以通过染色体和质粒介导,还可以通过主动外排系统中的基因突变引起多重可传递耐药,且耐药基因也可通过转化、接合等方式在淋球菌间传递。大观霉素和头孢曲松是我国治疗淋病的首选用药,不再推荐环丙沙星等氟喹诺酮类药物治疗淋病。沙眼衣原体为细胞内寄生菌,相对不易从其它病原体获得耐药基因,对抗生素耐药的机理与特性至今不明,但临床报道耐药多见。我国对沙眼衣原体感染的推荐治疗药物为阿奇霉素和多西环素,替代治疗药物包括红霉素和氧氟沙星等。
Drug resistance on Neisseria gonorrhoeae and Chlamydia trachomatis is common clinically. The former can be encoded not only by chromosome and plasmid, but also by mutant gene in active efflux system causing multiple transferable resistances. Resistance genes can transfer among Neisseria gonorrhoeae by transformation, conjugation or other mechanisms. Speetinomycin and cefiriaxone are the first choice for the treatment of gonorrhoeae in China. Chlamydia traehomatis is an intracellular parasitic bacterium and is relatively not easier to obtain resistance genes from other pathogens. The mechanism and characteristics of drug resistance of Chlamydia traehomatis are still unknown, though clinical reports on drug resistance are not rare. Azithromycin and c[oxycycline are recommended for treatment of non-gonococcal urethritis, eervicitis. The alternative treatment regimen includes erythromycin and ofloxacin.
出处
《上海医药》
CAS
2012年第1期11-12,15,共3页
Shanghai Medical & Pharmaceutical Journal
关键词
淋球菌
沙眼衣原体
耐药
Neisseria gonorrhoeae
Chlamydia trachomatis
drug resistance
