摘要
以2,3-二甲基-4-硝基吡啶-N-氧化物为原料,通过2个"一锅法",经4步反应合成兰索拉唑。改进的合成路线缩短了合成工艺流程提高了产品收率,反应条件相对温和。总收率达到39.2%,高于文献报道的18.8%,适合工业化生产。
The proton pump inhibitor,2-[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl methyl]sulfinyl-1H-benzimidazole was synthesized via 4 steps of reactions from the starting material 2,3-dimethyl-4-nitropyridine-N-oxide.The improved synthetic route increased the product yield and the reaction conditions mild relatively.The total yield was up to 39.2% exceeding literature value 18.8%
出处
《化工生产与技术》
CAS
2011年第6期6-7,30,共3页
Chemical Production and Technology
