摘要
以甲醇钠为缩合剂,2-氯甲基-3-甲基-4-(2,2,2-三氟乙氧基)吡啶盐酸盐与2-巯基苯并咪唑缩合,高收率(97%)地获得硫醚化合物(3);以过氧化氢-钼酸铵体系催化氧化3制得兰索拉唑,收率达81%。其结构经1H NMR和MS确证。
2-Chloromethyl-3-methyl-4-（2,2,2-trifluoroethoxy） pyridine hydrochloride and 2-mercaptobenzimidazole were condensed with sodium methoxide as a condensation agent in a high yield of 97% to afford a thioether compound, which was oxidize catalytically with the hydrogen peroxide -ammonium molybdate system to prepare Lansoprazole in a yield of 81%. Their structures were confirmed by ^1H NMR and MS.
出处
《合成化学》
CAS
CSCD
2007年第5期647-648,652,共3页
Chinese Journal of Synthetic Chemistry
关键词
兰索拉唑
缩合
氧化
过氧化氢
工艺改进
lansoprazole
condensation
oxidation
hydrogen peroxide
process improvement
