摘要
目的探讨Periostin蛋白在鼻咽癌患者中的表达以及与临床病理因素的相关性。方法选择87例鼻咽癌患者,分析患者的临床病理信息,包括年龄、性别、组织分化程度、肿瘤分级、淋巴结转移和远处转移等。每例患者采集手术前、后血清,用酶联免疫吸附测定(ELISA)检测患者血清Periostin蛋白水平,并分析其与临床病理因素的关系。65例健康志愿者的血清作为对照。结果鼻咽癌患者血清Periostin蛋白水平显著高于健康志愿者;患者血清Periostin蛋白水平与患者肿瘤组织分化程度、淋巴结转移有关;术后患者血清Periostin蛋白水平显著下降,但仍高于健康志愿者。化疗不影响血清Periostin蛋白水平。结论鼻咽癌患者血清periostin蛋白水平显著高于健康者,与患者的临床病理因素、淋巴结转移相关。
Objective To explore Periostein protein expression in serum of patients with nasopharyngeal carcinoma and its correlation with clinicopathologic factors.Methods 87 patients with nasopharyngeal carcinoma were selected.Clinicopathological information including age,gender,degree of histological differentiation,tumor grade,lymphatic metastasis and distant metastasis were analyzed.Serum samples from each patient were collected preoperatively and postoperatively,and enzyme-linked immunosorbent assay（ELISA） was employed to detect the serum level of Periostin protein,and its relation to clinicopathological factors was assayed.Serum samples of 65 healthy volunteers served as control.Results Serum levels of Periostin protein of patients with nasopharyn-geal carcinoma were significantly higher than those of healthy volunteers.The expression levels of serum Periostin protein were correlated with the histological differentiation degree of tumor and lymphatic metastasis.Serum Periostin levels of patients which weren′t affected by chemotherapy decreased markedly after operation,but were still higher than those of healthy volunteers.Conclusion Serum level of Periostin protein of patients with nasopharyngeal carcinoma which correlated with clinicopathological factors and lymphatic metastasis is higher than that of healthy people.
出处
《重庆医学》
CAS
CSCD
北大核心
2011年第36期3691-3693,共3页
Chongqing medicine
关键词
鼻咽肿瘤
细胞分化
淋巴转移
细胞因子类
骨膜蛋白
nasopharyngeal neoplasms
cell differentiation
lymphatic metastasis
cytokines
periostin
