摘要
目的：探讨血清白细胞介素８（ＩＬ－８）变化在白血病中的意义。方法：采用夹心酶联免疫吸附法测定了 １０例急性淋巴细胞白血病（ＡＬＬ），２５例急性非淋巴细胞白血病（ＡＮＬＬ），１１例慢性粒细胞白血病（ＣＭＬ）慢性期血清ＩＬ－８浓度。结果：ＡＬＬ＼ＡＮＬＬ和ＣＭＬ患者血清ＩＬ－８水平显著高于正常对照组（Ｐ＜０．０１），ＡＬＬ与ＡＮＬＬ患者无显著性差异（Ｐ＞０．０５），急性单核细胞白血病组水平显著高于急性粒细胞白血病（ Ｍ１～Ｍ３）组（Ｐ＜０．０５），治疗有效的ＣＭＬ患者，治疗后ＩＬ－８水平显著低于治疗前水平（Ｐ＜０．０５）。结论：ＩＬ－８的变化可作为ＡＮＬＬ分型及监测ＣＭＬ治疗反应的一种手段。
Objective:To study the clinical value significance of serum interleukin-8 (IL-8) in leukemia patients. Methods:Serum interleukin-8 levels were measured in 10 patients with acute lymphocytic leukemia(ALL), 25 with acute non- lym-phocytic leukemia(ANLL)and 11 with chronic myelogenous leukemia(CML)at chronic phase by sandwich enzyme linked immnosorbent assay (ELISA ). Results: Significantly higher IL- 8 were found in ALL, ANLL and CML patients compared to normal controls(p <0.01 ). There were no significant differences in IL-8 level between ALL and ANLL patients(p >0.05).Serum IL-8 levels in M5 patients was significantly higher than that of ANLL patients. IL-8 levels significantly declined after effective treatment in CML patients. Conclusion: Serum IL- 8 level may be helpful in typing of ANLL and in monitoring CML response to treatment.
出处
《新医学》
2000年第1期21-22,共2页
Journal of New Medicine
关键词
白细胞介素8
白血病
淋巴细胞
非淋巴细胞
Interleukin-8 Leukemia Lymphocyes Non--lymphocyes Myelogenous,chronic Enzymelnked immnosorbent assay
