摘要
目的评价胃肠动力治疗仪联合聚乙二醇粉治疗便秘型肠易激综合征(IBS)的疗效。方法采用随机、开放、平行、阳性药物对照方法进行研究。入选符合罗马Ⅱ标准的便秘型IBS患者90例,分为胃肠动力治疗仪组、胃肠动力治疗仪加聚乙二醇粉联合治疗组(联合治疗组)及莫沙比利组3组,每组30例。试验包括1周基线期,2周治疗期。根据患者临床症状及生活质量进行评分。结果治疗后,3组患者腹痛、腹胀症状均有改善,联合治疗组腹胀症状改善最明显。胃肠动力治疗仪组腹痛症状改善最明显。各组患者大便Bristol分级构成及生活质量较治疗前明显改善,差异均有统计学意义(P<0.05);其中联合治疗组、胃肠动力治疗仪组与莫沙比利组比较,差异均有统计学意义(P<0.05);联合治疗组与胃肠动力治疗仪组比较,差异无统计学意义(P>0.05)。结论应用胃肠动力治疗仪联合聚乙二醇粉治疗便秘型IBS疗效好。
Objective To evaluate the curative effect of the instrument gastrointestinal joint polyethylene glycol powder in treating constipation type irritable bowel syndrome （IBS）. Methods Use randomized, open, parallel, positive drug control methods to carry out the research. 90 cases with the Roman II standard IBS constipation were divided into 3 groups： the gastrointestinal instrument group, the gastrointestinal treatment with glycol combination therapy group and the Mosapride group, each with 30 cases. The tests included 1 week of baseline potSod and 2 weeks of treatment. Evaluae the curative effect according to the clinical symptoms and quality of life. Results The symptoms of abdominal pain, abdominal distension of the patients in these three groups were all relieved ＇with remarkable improvement of abdominal pain in the combination group and abdominal distension in gastrointestinal instrument group; the Fecal Bristol grading and the qulatiy of life were improved remarkably than those before treatment, with statistically significant difference （ P 〈 0. 05 ）. There was significant difference between combination therapy group and the Mosapride group, gastrointestinal group and the Mosapride group （ P 〈 0.05 ） ; There was no statistical significance between combination therapy group and gastrointestinal group （P 〉 0. 05）. Conclusion Using instrument gastrointestinal joint polyethylene glycol powder to treat constipation type IBS is the better method.
出处
《中国全科医学》
CAS
CSCD
北大核心
2011年第35期4057-4059,共3页
Chinese General Practice
关键词
肠易激综合征
胃肠动力治疗仪
聚乙二醇粉
Irritable bowel syndrome
Gastrointestinal instrument
Polyethylene glycol powder
