摘要
目的：探讨抑郁症患者在治疗前后P３００特点及其变化。方法：比较25例抑郁症和25例正常对照者P３００的测量数值，并根据临床疗效分为阿米替林治疗有效和治疗无效组，用配对t检验比较治疗前后P３００成分变化。结果：抑郁症与对照组比较，N２潜伏期延长(P＜005)，P３潜伏期延长(P＜001)，P3波幅降低(P＜001)，治疗无效组治疗后比治疗前P３波幅增高(P＜005)，P３潜伏期未见明显差异，治疗有效组治疗后P３潜伏期显著缩短(P＜001)，波幅增高，但无显著性。讨论：P３００主要成分的异常，反映了抑郁症患者认知功能存在障碍，并可用其作为评定抑郁症疗效的参考指标。
Objectve:To explore the characteristics of event related potentials (ERPs) P３００ in patients with depression. Methods:Values of P３００ of 25 patients with depression were compared with those of 25 normal controls. Depression patients were divided into amitriptylineeffective group and amitriptylineresistant group by clinical treatment effects. Paired ttest was used to compare the changes of P３００before/after treatment in two groups. Result:As compared with the control group, the latencies of N2 and P3 were prolonged (P＜05，P＜001) and the amplitude of P3 was reduced (P＜001) in depression patients. Conclusion:Abnormality of P３００ component of ERP in depression patient reflected their cognitive impariment, Ｐ300 might be served as a referent index for therapeutic effect.
