摘要
目的:研究大黄总蒽醌对SD大鼠的急性肾毒性作用。方法:SD大鼠连续3天灌胃给药,观察大鼠一般情况,检测血、尿及肾脏组织学改变。结果:SD大鼠灌胃高剂量药物后,大鼠一般情况和血液、尿液、肾脏组织均有显著性差异。结论:大黄总蒽醌对大鼠存在一定肾毒性。
Objective ： Research of the effect of total rhubarb anthraquinone on acute kidney toxicity of SD rats. Methods：Lavaging stomachs of SD rats for 3 consecutive days .Observing general rats and testing blood, urine and renal lesion. Results ： SD rats ig high doses, rats under the general condition and blood, urine and kidney tissue were significantly different. Conclusion ： Rhubarb total anthraquinone exists certain renal toxicity to rats.
出处
《辽宁中医药大学学报》
CAS
2012年第1期69-71,共3页
Journal of Liaoning University of Traditional Chinese Medicine
基金
国家科技支撑计划资助项目(2011BAI04B04)
关键词
大黄
总蒽醌
急性肾毒性
rhubarb
total anthraquinone
acute kidney toxicity
