摘要
目的观察盐酸法舒地尔治疗急性脑梗死时对血浆血管紧张素Ⅱ(AngⅡ)和降钙素基因相关肽(CGRP)浓度的影响及其临床疗效。方法将100例入院诊断为急性脑梗死患者随机分为对照组50例和治疗组50例。两组均用奥扎格雷钠治疗,治疗组加用盐酸法舒地尔。治疗前、后分别进行神经功能缺损程度评分及血浆AngⅡ和CGRP浓度及头颅MRI和DWI检查。结果治疗组和对照组总有效率分别为94.9%和78.9%,前者明显高于后者,且差异有统计学意义(P<0.05)。两组血浆AngⅡ降低和CGRP浓度升高,但上述两者浓度的改变在治疗组比对照组更明显(P<0.05)。结论盐酸法舒地尔能调整AngⅡ和CGRP水平失衡、促进脑循环及脑保护有关,能有效改善急性脑梗死患者的临床预后。
Objective To evaluate the clinical effects of Ang Ⅱand CGRP of fasudil hydrochloride on patients with acute cerebral infarction.Methods One hundred cases of acute cerebral infarction patients were randomly divided into treatment group（n=50） and control group（n=50）.the plasma concentrations of Ang Ⅱ and CGRP were detected while the scorces of neuro-logical deficit（NDS）were evaluated before and after treatment.Results Basic recovery rate and total effective rate of treatment group were significantly higher（P0.05） than control group.Neurological deficit scorces（NDS） of treatment group significantly decreased（P0.05） than control group.Level of Ang Ⅱ and CGRP in two groups are obviously decreased and reduced more significant in treatment group（P0.05） compared with the control group.Conclusion Fasudil hydrochloride can effectively improve the clinical prognosis of patients with acute cerebral infarction,and the effections may related with the fasdil reduce the level of Ang Ⅱ and CGRP.
出处
《当代医学》
2011年第36期19-20,共2页
Contemporary Medicine
