摘要
目的探讨磁导向纳米磁微粒定向栓塞脑动静脉畸形(CAVM)的有效性和可靠性。方法将建立了CAVM模型的15头小猪随机分为3组:磁导向组(聚焦磁场导向,n=6),非磁导向组(无聚焦磁场导向,n=6)和对照组(不做任何处理n=3),前两组均采用纳米磁微粒栓塞CAVM。分别在栓塞后1周进行DSA和B超声检查,观察栓塞效果。结果磁导向组在栓塞1周后DSA显示,CAVM和引流静脉几乎全部消失。术后1周B超示引流静脉无血流,右侧颈静脉血栓形成;平均流速为0,与非磁导向组的(70.22±2.26)cm/s和对照组的(75.53±2.24)cm/s相比,差异显著(P<0.01)。结论实验证实在磁场作用下,纳米磁微粒可以有效地、可靠地靶向栓塞小猪的CAVM。这可能为临床治疗CAVM提供了新的途径和栓塞材料。
Objective To explore the reliability and effectiveness of magnetism-guided endovascular embolization of the cerebral arteriovenous malformations （CAVM） by magnetic albumin nanopartieles （MAN）. Methods Fifteen pigs with CAVM established by Massoud method were divided into three groups, i.e. Magnetism-guided （with focusing magnetic field） group （n=6）, no magnetism-guided （without focusing magnetic field） group （n=6） and control （without any treatment） group （n=3）. CAVM were endovascularly embolized by MAN in the animals of both the magnetism-guided and no magnetism-guided groups. All the animals were examined by DSA and B ultrasound respectively a week after the embolization in order to assess the effect of the embolization on CAVM. Results DSA showed that CAVM were completely embolized in the magnetism-guided group and CAVM were unchanged in the no magnetism-guided group and control group. B ultrasound showed that the drainage veins of CAVM had no blood flowing in the magnetism-guided group. Conclusion CAVM in the pigs can be embolized successfully by the targeting-biodistribution MAN. It is suggested that targeting-biodistribution MAN may be clinically used for the endovaseular embolization of CAVM.
出处
《中国临床神经外科杂志》
2011年第12期735-737,共3页
Chinese Journal of Clinical Neurosurgery
基金
国家自然科学基金(NO:30772220)
天津市自然科学基金(NO:07JCYBJC10400)
关键词
脑动静脉畸形
模型
纳米磁微粒
定向栓塞
小猪
Cerebral arteriovenous malformation
Magnetic nanoparticles
Magnetism
Guidance
Pig
