摘要
背景:既往国内外研究中,主要针对肿瘤患者体内葡萄糖的摄取情况,而关于正常人在空腹状态下不同器官对葡萄糖的摄取作用研究很少。目的:正电子发射断层成像/CT观察健康人在空腹状态下不同器官对18F脱氧葡萄糖的摄取情况,分析空腹时脑、肝、肾、心脏和骨骼肌组织在糖代谢中的相关性。方法:31例健康成年人空腹抽血测肝肾功能、血糖和血脂,并行正电子发射断层成像/CT检查,测脑、心脏、肝、肾脏和骨骼肌的18F脱氧葡萄糖的平均标准摄入值以及最大标准摄入值。结果与结论:空腹时脑皮质18F脱氧葡萄糖的平均标准摄入值约是心脏和肾脏的两三倍,是肝脏的4倍左右,是骨骼肌的15倍。肝脏平均标准摄入值与肾脏和骨骼肌的平均标准摄入值呈显著正相关(r=0.406,0.391,P=0.023,0.030),但肝脏的平均标准摄入值与心和脑的平均标准摄入值无相关性。结果提示空腹状态下脑组织对葡萄糖摄取最多,骨骼肌最少,心脏、肝脏和肾脏居中;空腹状态下肝脏与肾脏和骨骼肌之间对葡萄糖的代谢存在显著相关性。
BACKGROUND：Previous studies in home and aborad were mainly focus on glucose uptake of cancer patient in vivo,but few studies for glucose intake in different organs of normal people under fasting.OBJECTIVE：To observe 18F-fluorodeoxyglucose（FDG） uptake of different organs in healthy adults under fasting by using positron emission tomography（PET）/CT and to analysis the correlation of glycometabolism and healthy adults with brain,liver,kidney,heart and skeletal muscle tissue.METHODS：Totally 31 healthy adults were treated with liver and kidney functions,blood glucose and triglyceride conventionally test under fasting.Mean and maximum standardized uptake value（SUV） of 18F-FDG with brain,heart,liver,kidney and skeletal muscle were detected by combined PET/CT scanner.RESULTS AND CONCLUSION：Under fasting,SUV mean of 18F-FDG in brain was two or three times larger than that in heart and kidney,about four times larger than that in liver and 15 times larger than that in skeletal muscle.There were significant positive interrelationships of SUV mean among skeletal muscle,kidney and liver（r=0.406,0.391,P=0.023,0.030）,but the SUV mean in kidney was no correlation with the heart and brain.It is indicated that under fasting,the quantity of glucose uptake of brain is greater,while of skeletal muscle is fewer,and of heart,liver,kidney is between the brain and the skeletal muscle tissue.There is a significant correlation of glycometabolism among liver,kidney and skeletal muscle under fasting.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2011年第48期9027-9030,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
基金
南京市医学重点科技发展项目(ZKX10016)~~
