摘要
目的:观察不同剂量的辛伐他汀对冠状动脉造影(CAG)和经皮冠状动脉成形术(PCI)后患者肾功能损害的预防作用。方法:将我院115例行CAG或PCI术的患者,随机分为常规剂量组(n=57)和大剂量组(n=58)。2组均于术前2～3d开始用药,常规剂量组给予辛伐他汀10mg,每晚1次;大剂量组给予辛伐他汀40mg,每晚1次。所有患者分别于术前,术后第1天、第2天空腹测定血液流变学指标。结果:术后第2天,2组血清胱抑素(CysC)、尿α1-微球蛋白(α1-MG)、尿微量白蛋白(mALB)均显著降低,且大剂量组下降幅度更明显(P<0.05)。结论:CAG和PCI术前短期给予大剂量的辛伐他汀对改善造影剂所致肾损害可能更有效。CysC、α1-MG、mALB可能成为CAG和PCI术后监测早期肾损害的指标。
To study the effect of different doses of simvastatin on renal function of patients who underwent coro- nary angiography （CAG） and percutaneous coronary intervention （PCI）. METHODS： 115 patients who underwent CAG or PCI were randomly divided into conventional dose group （n=57） and high dose group （n=58）. Conventional dose group were fed with simvastatin 10 nag every night and high dose group were fed with 40 mg every night during 2-3 days before surgery. Blood rheodogy was detected before the surgery, the 1st day and the 2nd day after surgery. RESULTS： Compared with before surgery and conventional group, the levels of Cys C, a1-MG and mALB at the 2nd day after the surgery were decreasing significantly （P〈 0.05）. And the high dose group decreased lower than conventional group （P〈0.05）. CONCLUSION： Before CAG and PCI, short-term high doses of simvastatin may be more effective on the improvement of renal damage caused by contrast agents. Cys C, a1-MG and mALB can be monitored as an early indicator of renal damage after CAG and PCI.
出处
《中国药房》
CAS
CSCD
北大核心
2011年第48期4575-4578,共4页
China Pharmacy
关键词
辛伐他汀
造影剂
肾功能损害
冠状动脉介入术
Simvastatin
Contrast media
Renal fimction damage
Percutaneous coronary intervention
