摘要
目的探讨前列地尔对冠心病合并糖尿病患者经皮冠状动脉介入(PCI)术后对比剂肾病(CIN)的预防作用。方法选取长沙医学院附属永州市第三人民医院2015年3月—2016年10月收治的行PCI术治疗的冠心病合并糖尿病患者72例,随机分为对照组和观察组,各36例。对照组患者给予常规治疗,观察组患者在对照组基础上给予前列地尔治疗。比较两组患者治疗前后血肌酐(Scr)、尿素氮(BUN)、血清胱抑素C(Cys-C)、β2微球蛋白(β2-MG)、肾小球滤过率(GFR),并记录比较两组患者CIN发生情况。结果治疗前,两组患者Scr、BUN、Cys-C、β2-MG及GFR比较,差异无统计学意义(P>0.05);治疗后,观察组患者Scr、BUN、Cys-C、β2-MG低于对照组,GFR高于对照组(P<0.05)。观察组患者CIN发生率低于对照组(P<0.05)。结论前列地尔在冠心病合并糖尿病患者PCI术中的应用效果确切,可有效改善患者的肾功能,降低CIN发生。
Objective To study the preventive effect of alprostadil in contrast induced nephropathy（CIN） of patients with coronary heart disease and diabetes mellitus underwent percutaneous coronary interention（PCI） surgery.Methods A total of 72 cases of coronary heart disease with diabetes mellitus patients underwent PCI surgery were selected from March 2015 to October 2016 in Changsha Medical University Affiliated the Third People＇s Hospital of Yongzhou,which were randomly divided into control group and observation group,36 cases in each group.Control group was given conventional therapy,observation group was given alprostadil based on control group.The Scr,BUN,Cys-C,β2-MG,GFR before and after treatment were compared between the two groups,and the incidence of CIN was recorded and compared between the two groups.Results Before treatment,no statistically significant differences of Scr,BUN,Cys-C,β2-MG or GFR was found between the two groups（P〉0.05）;after treatment,the observation group of Scr,BUN,Cys-C,β2-MG were lower than control group,GFR was higher than control group（P〈0.05）.The incidence of CIN of observation group was lower than control group（P〈0.05）.Conclusion Alprostadil has a better application effect in coronary heart disease with diabetes mellitus patients underwent PCI surgery,it can effectively improve the kidney function,and reduce the incidence of CIN.
出处
《临床合理用药杂志》
2017年第18期1-2,共2页
Chinese Journal of Clinical Rational Drug Use
