摘要
以取代苯甲醛和丙二酸合成的5种肉桂酸及其衍生物、苯甲酸和对甲氧基苯甲酸为初始原料,合成了7种未见文献报道的芥子碱类似物6a～6g,经IR、1H NMR及元素分析对目标化合物结构进行了表征。以家兔离体肠平滑肌为测试对象,研究了所合成的7种芥子碱类似物对平滑肌张力的影响,结果显示化合物6a、6d和6g对家兔离体肠平滑肌有舒张作用,6f有收缩作用。
Seven sinapine analogs（6a-6g） were synthesized using cinnamon acid or benzoic acid and their derivatives as starting materials,which obtained from substituted benzaldehyde and malonate.The structures of target compounds were characterized by IR,1H NMR and elemental analysis.The effects of compounds 6a-6g on the smooth muscle of intestine isolated from rabbit were studied,and the experimental results showed that compounds 6a,6d and 6g had diastolic action,while 6f had contractile action.
出处
《药学学报》
CAS
CSCD
北大核心
2011年第12期1466-1470,共5页
Acta Pharmaceutica Sinica
基金
辽宁省教育厅优秀人才支持项目(2008RC03)
关键词
芥子碱
合成
平滑肌张力
sinapine
synthesis
smooth muscle tension
