摘要
缺血性脑卒中（Is）是一种复杂的多因素、多基因遗传变异性疾病，遗传因素在其发病机制中起重要作用。动脉粥样硬化作为一种慢性炎症性疾病，是缺血性脑卒中的主要病因。白三（LT）烯生物合成通路参与炎症反应，引发血管炎症和动脉粥样硬化的形成。本文对白三烯生物合成通路遗传变异影响、缺血性脑卒中发病的分子机制及两者的相关性研究做一综述。
Objective Ischemic stroke is a complex multifactorial and polygenic genetic heterogeneity disease. Genetic factors play vital roles in its pathogenesis. Atheroselerosis, a chronic inflammation disorder, is the main cause of isehemic stroke. Leukotriene biosynthesis pathway is involved in the inflammatory response, initiating the vascular inflammation and the formation of atherosclerosis. This article reviews the molecule mechanism of genetic variation of the leukotriene biosynthesis pathway affecting ischemic stroke and the association study between them.
出处
《中国急救医学》
CAS
CSCD
北大核心
2011年第12期1126-1129,共4页
Chinese Journal of Critical Care Medicine
基金
江苏省卫生厅科研项目（No.H201005）
