摘要
目的探讨美金刚联合尼莫地平对高龄老年中重度血管性痴呆患者认知功能和行为能力的疗效及安全性。方法将50例高龄老年血管性痴呆患者,简易精神状态检查表(MMSE)分数介于7至20之间,随机分为3个组,在治疗前和治疗12周后进行MMSE、日常生活活动能力量表(ADL)和临床痴呆评定量表(CDR)的评分并比较三组的评分结果,同时观察不良反应。结果单用美金刚治疗组治疗后MMSE评分为(18.7±4.5)分,ADL评分为(30.7±11.5)分,较对照组[分别为(15.9±4.6)分和(34.9±11.8)分]有显著改善(P<0.05);联合用药组治疗后MMSE评分为(21.2±3.9)分,ADL评分为(26.5±10.6)分,较单用美金刚治疗组有显著改善(P<0.05),三组不良反应发生率差异没有统计学意义(P>0.05)。结论美金刚能有效改善高龄老年中重度血管性痴呆患者的认知功能及日常生活能力,与尼莫地平联合治疗效果更好,并有较高的安全性。
Objective To explore the clinical efficacy and safety of memantine combined with nimodipine in improving cognitive function and behavioral capacity in senile elderly vascular dementia patients.Methods Fifty senile elderly vascular dementia patients with Minimental State Examination（MMSE）scores between 7 and 20 were randomly divided into 3 groups.MMSE,Activit of Daily Livings Scale（ADL） and Clinical Dementia Rating Scale（CDR） scores were assessed before treatment and after 12 weeks of treatment.A comparative study was made to evalate the curative effects and side effects between the 3 groups.Results MMSE and ADL scores of memantine group（18.7±4.5,30.7±11.5,respectively） improved significantly when compared with control group（15.9±4.6,34.9±11.8,respectively）,and the difference was significant（P（0.05））.There was a significant difference in MMSE and ADL scores between combined group（21.2±3.9,（26.5）±10.6,respectively） and memantine group（P0.05）.The incidence of adverse reactions showed no difference between 3 groups（P0.05）.Conclusion Memantine can effectively improve the cognitive function and daily living skills in senile elderly vascular dementia patients.Its combination with nimodipine is superior to its single use with a higher safety.
出处
《东南国防医药》
2011年第6期515-517,共3页
Military Medical Journal of Southeast China
关键词
美金刚
尼莫地平
血管性痴呆
高龄老年
memantine
nimodipine
vascular dementia
senile elderly patients
