摘要
目的综述计算机辅助成型技术制备骨组织工程支架的应用和相关研究进展。方法广泛查阅近年有关计算机辅助成型技术制备骨组织工程支架的文献,并进行综述。结果近10余年来许多研究致力于计算机辅助成型技术制备骨组织工程支架。该技术包括骨支架建模和骨支架快速成型,骨支架建模方法包括医学计算机辅助设计界面法、STL界面法和反求界面法,反求界面法可以完全模拟正常骨组织,是目前最好的建模方法。快速成型包括多种方法,如熔融沉积技术、三维打印技术、选择性激光烧结技术、三维生物描绘技术、低温沉积制造技术,可以制备出包含骨骼内部结构的三维孔隙结构。结论随着支架建模和制造成型技术的不断改进,计算机辅助成型技术将成为制备骨组织工程支架的主要有效手段。
Objective To review recent advance in the research and application of computer aided forming techniques for constructing bone tissue engineering scaffolds.Methods The literature concerning computer aided forming techniques for constructing bone tissue engineering scaffolds in recent years was reviewed extensively and summarized.Results Several studies over last decade have focused on computer aided forming techniques for bone scaffold construction using various scaffold materials,which is based on computer aided design（CAD） and bone scaffold rapid prototyping（RP）.CAD include medical CAD,STL,and reverse design.Reverse design can fully simulate normal bone tissue and could be very useful for the CAD.RP techniques include fused deposition modeling,three dimensional printing,selected laser sintering,three dimensional bioplotting,and low-temperature deposition manufacturing.These techniques provide a new way to construct bone tissue engineering scaffolds with complex internal structures.Conclusion With rapid development of molding and forming techniques,computer aided forming techniques are expected to provide ideal bone tissue engineering scaffolds.
出处
《中国修复重建外科杂志》
CAS
CSCD
北大核心
2011年第12期1508-1512,共5页
Chinese Journal of Reparative and Reconstructive Surgery
基金
天津市应用基础与前沿技术研究计划面上项目(08JCYBJC05800)
天津市企业博士后科技创新择优资助计划~~
关键词
骨组织工程
计算机辅助成型技术
快速成型技术
骨支架
Bone tissue engineering Computer aided forming technique Rapid prototyping technique Bone scaffold
