摘要
创伤、炎症和肿瘤等病理性因素或先天因素导致的骨缺损的治疗,特别是大段骨缺损的治疗是临床上的难点之一。现有骨缺损治疗方法主要包括骨移植（自体、同种异体和异种骨移植）、植入人工生物材料和牵张成骨等,但均不能取得满意的效果[1]。近年来,快速发展的骨组织工程技术为骨缺损的修复提供了一种新的方法。骨组织工程包括种子细胞、支架材料和细胞因子三个基本要素。支架材料作为骨组织工程的基础,其结构特征对骨缺损修复的最终效果具有非常重要的影响。
Bone tissue engineering includes 3 basic factors： cells, scaffolds and cytokines. The fast developments of bone tissue engineering provide new approaches for better restoration and reconstuction. Among them, new methods to fabricate optimal personalized scaffolds by three-dimensional（ 3 D） bioprinting technique draw much attention. 3 D bioprinting is a branch of 3 D printing in biomedicine. It builds up a 3 D structure by printing with biomaterials and / or cells（ cytokines）. As a novel technique in tissue engineering, 3 D bioprinting performs better than traditional techniques. It can fabricate personalized scaffolds with high porosity and proper pore size easily and rapidly, and the scaffolds can meet the requirement of biocompatibility and mechanical strength in tissue engineering. Moreover, cells or cytokines can be deposited into biomaterials during printing, which can make the scaffolds both osteoinductive and osteoconductive. Although 3 D bioprinting has already been applied, it is still at a preliminary stage and improvement is still in need. It is important to search for the suitable approach for the deposition of cells and cytokines, to explore the way to maintain the bioactivity, and to develop new biomaterials for 3 D biopringting. With the development of medical imaging, digital medicine and new biomaterials, 3 D bioprinting will be used more and more in bone tissue engineering.
出处
《中国骨与关节杂志》
CAS
2015年第11期852-856,共5页
Chinese Journal of Bone and Joint
基金
国家自然科学基金(81400486)
江苏省自然科学基金(BK20140911)
江苏省博士后基金(1402044B)
中国博士后基金(2015M571647)
江苏高校优势学科建设工程资助项目(2014-37)
关键词
组织工程
生物相容性材料
细胞因子类
计算机辅助设计
三维打印
Tissue engineering
Biocompatible materials
Cytokines
Computer-aided design
Bioprinting
three-dimensional
