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冠心病患者糖代谢状态对肱动脉内皮功能和颈动脉粥样硬化的影响 被引量:7

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摘要 目的探讨冠心病患者糖代谢状态对肱动脉内皮功能和颈动脉粥样硬化的影响。方法 209例冠心病患者按糖代谢状态分为糖代谢正常组、糖调节受损组和糖尿病组,利用高频超声检测其肱动脉内皮功能和颈动脉内中膜厚度与斑块,并记录患者年龄、性别、血压、血脂、血糖、hsCRP和肾功能资料。结果 3组间年龄、性别、血压、血脂差异无统计学意义。FPG、2hPG、糖化血红蛋白和hsCRP逐渐升高,差异有统计学意义,并且两两比较差异有统计学意义。3组间肱动脉内皮功能逐渐减低,颈动脉内中膜厚度逐渐增加,斑块发生率也度逐渐增加,差异均有统计学意义,并且两两比较差异有统计学意义。多元逐步回归分析表明颈动脉内中膜厚度的独立影响因素为年龄、FPG、2hPG、糖化血红蛋白、hsCRP和肱动脉内皮功能;肱动脉内皮功能的独立影响因素为年龄、FPG、2hPG、糖化血红蛋白和hsCRP。结论冠心病患者肱动脉内皮功能和颈动脉粥样硬化与糖代谢状态相关,hsCRP可能在其中起重要的介导作用。超声检查在评价冠心病患者糖代谢状态对肱动脉内皮功能和颈动脉粥样硬化的影响中具有重要作用。
出处 《广东医学》 CAS CSCD 北大核心 2011年第17期2268-2270,共3页 Guangdong Medical Journal
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