摘要
目的:探讨2型糖尿病(T2DM)患者白蛋白尿与颈动脉内膜中层厚度的关系。方法:146例T2DM患者行24h尿微量白蛋白检测,根据结果分为正常白蛋白尿组(86例)和异常白蛋白尿组(60例,包括微量白蛋白尿组和大量白蛋白尿组),对2组患者分别进行各项生化指标及颈动脉内膜中层厚度(IMT)的检测,并对2组数据进行单因素、多因素Logistic回归分析,比较正常尿、微量白蛋白尿(MAU)以及大量白蛋白尿3组间颈动脉IMT的差异。结果:病程、视网膜病变发生率、三酰甘油、颈动脉IMT和血肌酐是2型糖尿病白蛋白尿的影响因素;病程长、三酰甘油高、颈动脉IMT增厚、血肌酐增高是2型糖尿病患者白蛋白尿的独立危险因素(OR值分别为1.105、1.528、12.781和1.029)。3组间颈动脉IMT比较差异有统计学意义(P<0.01),而微量白蛋白尿组与大量白蛋白尿组之间比较差异无统计学意义(P>0.05)。结论:2型糖尿病患者颈动脉IMT是白蛋白尿的一个独立危险因素,糖尿病肾病的严重程度增加,颈动脉IMT无明显增厚。
Objective：To investigate the relationship between the albuminuria and carotid artery intima-media thickness （IMT） in type 2 diabetes mellitus （T2DM）. Methods： The value of 24-hour urine microalbumin was detected in 146 T2DM patients. Based on the results the patients were divided into normal albuminuria group （86 cases） and abnormal albuminuria group （60 cases）. Patients in abnormal albuminuria group were sub-divided into microalbuminuria group and macro-albuminuria group. The various biochemical indices and carotid artery IMT were detected in these two groups. The data were analyzed by the single factor, multi-factor Logistic regression analysis. The differences of carotid IMT were compared by variance analysis between the three groups. Results： The risk factors of albuminuria included the duration of illness, incidence of retinopathy, triglyceride, carotid artery IMT and serum creatinine. The independent risk factors of albuminuria included the longer duration, higher triglycerides, carotid artery IMT thickening and increased serum creatinine in patients with T2DM （the OR values were 1.105, 1.528, 12.781 and 1.029 respectively）. There were significant differences in carotid artery IMT between the three groups （P 0.01）, while there was no statistically significant difference between the microalbuminuria and macroalbuminuria groups （P 0.05）. Conclusion： The carotid artery IMT is an independent risk factor of albuminuria in T2DM patients. There was no significant thickening of carotid IMT with the increasing of the severity of diabetic nephropathy.
出处
《天津医药》
CAS
北大核心
2010年第11期957-959,共3页
Tianjin Medical Journal
关键词
糖尿病
2型
颈动脉
内皮
血管
糖尿病肾病
白蛋白尿
LOGISTIC模型
diabetes mellitus type 2 carotid arteries endothelium vascular diabetic nephropathies albuminuria Logistic models
