摘要
目的探讨瘦素、脂联素及瘦素与脂联素比值（L／A）与维持性血液透析患者动脉粥样硬化的关系。方法选择维持性血液透析患者（血液透析组）60例和正常对照组30例，采用双抗体夹心酶联免疫吸附技术测定血清脂联素及瘦素，采用血压脉搏测量装置CAVI-VaSeraVS-1000检测心踝血管指数（CAVI）。结果血清瘦素、脂联素在血液透析组显著高于正常对照组[分别为（7．99±1．21）wg／L与（4．18±1．10）彬L，（15．12±4．68）mg／L与（8．58±2．23）mg／L，P均〈0．01]。CAVI≥9．0患者血清瘦素显著高于CAVI〈9．0患者[（8．45±1．09）μg／L与（6．97±1．32）μg／L]，而脂联素则显著降低[（10．75±3．32）mg／L与（16．344-4．57）mg／L]（P均〈0．05）。L／A在CAVI≥9．0组显著升高（O．85±0．12与0．484-0．08）。多因素逐步回归分析显示影响CAVI的因素有年龄、糖尿病、瘦素、L／A，其中L／A的影响因素最大。结论维持性血液透析患者血清瘦素、脂联素升高，随着透析患者动脉硬化的进展，脂联素反而下降，升高瘦素和降低脂联素可能参与了血液透析患者动脉粥样硬化的发生、发展。
Objective To investigate the association of serum leptin （LEP）, adiponectin （ADPN） and leptin-to-adiponectin（L/A） ratio with cardio ankle vascular index （CAVI） in the patients maintaining hemodialysis （MHD）. Methods Sixty MHD patients and thirty healthy volunteers were involved in the study. The levels of LEP and ADPN were determined by ELISA. Atherosclerosis was evaluated by the cardio ankle vascular index which was measured by using a VaSera VS-1000 machine. Results The levels of serum LEP and ADPN in hemodialysis patients were significantly higher than those in healthy controls（ [7. 99 ＋ 1.21 ] μg/L vs. [4. 18 ＋ 1.10] μg/L） and （ [ 15.12 ±4. 68 ] mg/L vs. [ 8.58 ＋ 2. 23 ] mg/L） ,respectively,P 〈 0. 01 ] With the progression of atherosclerosis, the levels of serum LEP increased significantly, while the levels of serum ADPN decreased significantly. The L/A ratio was dramatically increased in patients with athereselerosis. Multiple stepwise regression analysis showed that independent risk factors associated with CAVI include age, diabetes, levels of LEP and L/A ratio. Conclusion The increased serum LEP level and decreased serum ADPN level may be involved in the progression of atherosclerosis in MHD patients. The L/A ratio may be a powerful independent predictor for CAVI in MHD patients.
出处
《中国综合临床》
2011年第11期1141-1144,共4页
Clinical Medicine of China
基金
北京市西城区卫生系统优秀人才培养专项经费资助项目（20080028）
关键词
瘦素
脂联素
心踝血管指数
维持性血液透析
动脉粥样硬化
Leptin
Adiponectin
Cardio ankle vascular index
Maintenance hemodialysis
Atheroselerosis
