摘要
目的研究伴有中央-颞区棘波的儿童良性癫癎(BECT)患儿共患注意缺陷多动障碍(ADHD)的特点及Rolandic电发放与ADHD亚型之间的关系。方法 6个月内无发作且未服用过抗癫癎药物的BECT患儿77例行VEEG检查,按NREMⅠ期及Ⅱ期Rolandic区癫癎样放电指数是否≥20分为A组和B组,另设保健门诊体检的儿童40例为对照组。根据美国精神病学会出版的《精神障碍诊断与统计手册》第四版(DSM-IV)中ADHD的诊断标准对三组儿童进行诊断与分型及比较分析。结果 A组(Rolandic区放电指数≥20者)39例,其中ADHD儿童17例,检出率为43.6%;B组(Rolandic区放电指数<20者)38例,ADHD儿童8例,检出率为21.1%;对照组中有1例ADHD儿童,检出率为2.5%,三组间ADHD检出率的差异具有统计学意义(χ2=19.33,P<0.01)。A、B两组BECT儿童中仅左侧Rolandic区放电的有29例,其中ADHD 9例,检出率为31.0%;右侧Rolandic区放电的有33例,其中ADHD 10例,检出率为30.3%;双侧Rolandic区放电的有15例,其中ADHD6例,检出率为40.0%。不同放电部位ADHD检出率的差别无统计学意义(P>0.05)。A、B两组儿童的ADHD分型差异无统计学意义(P>0.05)。结论 BECT儿童的Rolandic区电发放可能与ADHD的高发病率有关;BECT患儿共患ADHD的亚型与有无癎性放电有关。
Objective To study the features of children affected by both benign epilepsy of childhood with centro-temporal spikes（BECT）and attention-deficit hyperactivity disorder（ADHD）,and the relationship between discharge from Rolandic area and ADHD subtypes.Methods Seventy-seven BECT patients without using antiepileptic drugs and no seizure for six months were divided,based on sharp/spike discharge indexes in Rolandic area in NREM Ⅰ and Ⅱ,into group A（≥ 20）and group B（ 20）,when EEG examination were performed to them.Forty children for routine physical examination were included in the control group.All children of the three groups were evaluated for ADHD and diagnosed as PIT,HIT and CT based on the diagnostic criteria for ADHD in Diagnostic and Statistical Manual of Mental Disorders IV published by the American Psychiatric Association.Results Group A had 39 patients,including 17 cases（43.6%）affected by both BECT and ADHD;Group B had 38 patient,including 8 cases（21.1%）affected by both BECT and ADHD.Control group had only 1 case of ADHD（2.5%）.Detection rate of ADHD among the three groups was statistically significant difference（P〈0.01）.Discharged in the left Rolandic area was found in 29 BECT patients,and 9 of them were also diagnosed as ADHD with the detection rate of 31.0%（9/29）;Discharged in the right Rolandic area was found in 33 BECT patients,and 10 of them were also diagnosed as ADHD with detection rate of 30.3%（10/30）;Discharged in bilateral area was found in 15 BECT patients,and 6 of them were also diagnosed as ADHD with detection rate of 40.0%（6/15）.The detection rate of ADHD in different parts had no significant difference（P〉0.05）.There was no significant difference in sub-type of ADHD between A and B groups（P〉0.05）.Conclusions Discharge from Rolandic area of BECT children had a high incidence of ADHD.The subtypes of ADHD in BECT children were related to the epileptic discharge.
出处
《临床儿科杂志》
CAS
CSCD
北大核心
2011年第11期1020-1023,共4页
Journal of Clinical Pediatrics
基金
广州市医药卫生科技基金资助项目(No.2009-YB-073)
