摘要
目的分析急性肾损伤(AKI)的病因,探讨影响其预后的危险因素,为早期发现、早期预防和提高疗效提供帮助。方法选择2008年10月—2010年10月就诊于台州市第一人民医院的AKI患者为研究对象,归纳引起AKI的病因,将资料完整的426例AKI患者分为治愈组、好转组、无效组和死亡组,采用单因素分析初步筛查出影响预后的因素,然后将初筛有统计学意义的因素为自变量进行Logistic回归分析,判断各因素对死亡风险的影响。结果 (1)AKI患者426例,男268例(占62.91%),女158例(占37.09%),男女比约1.7∶1。平均年龄(43.3±14.8)岁;(2)按照引起AKI的原因分类,肾实质病变和梗阻性肾病所占比例最大(分别为23.71%和20.66%),其次是感染和药物性因素(分别占13.15%和11.50%)。(3)Logistic回归分析显示,多脏器功能障碍综合征(MODS)器官衰竭数目、高血钾和血红蛋白是影响AKI患者预后的因素(P<0.01)。结论肾实质损害、肾后梗阻、感染和药物是引起AKI的常见原因。MODS和高血钾是AKI患者预后的危险因素,血红蛋白是保护因素。
Objective To investigate the etiology and risk factors which influence the development of acute kidney injury（AKI） in favor of early detection,early prevention and better curative effects of the disease.Methods AKI patients from The First People′s Hospital of Taizhou between Oct 2008 and Oct 2010 were enrolled in this study with the AKI etiology summarized.A total of 426 AKI patients with complete clinical data were divided into four groups：the healed group,the improved group,the invalid group,and the death group.SPSS13.0 software was used to analyze the data of the clinical trial.We used t-test,Chi-square analysis and Logistic regression analysis to explore the risk factors which influenced the development of AKI.Results Among the 426 cases studied（average age：43.3±14.8）,268（62.91%） were males and 158（37.09%） were females,with a male to female ratio of 1.7∶ 1.According to etiology classification,renal parenchyma injury and obstruction topped all the causes of AKI,accounting for 23.71% and 20.66% respectively,with infections and the use of drugs followed（13.15% and 11.50% respectively）.Logistic regression analysis revealed that multiple organ dysfunction syndromes（MODS）,high level of serum potassium and low level of hemoglobin were influencing factors of the prognosis of AKI patients（P0.01）.Conclusion Renal parenchyma injury,obstruction,infections and the use of drugs are common causes of AKI.MODS,high level of serum potassium and low level of hemoglobin are risk factors for the prognosis of AKI patients.
出处
《中国全科医学》
CAS
CSCD
北大核心
2011年第32期3696-3698,共3页
Chinese General Practice
关键词
急性肾损伤
病因
预后
危险因素
Acute kidney injury
Etiology
Prognosis
Risk factors
