摘要
The aldol reaction of the silyl enol ether of cyclopent-2-enone with aldehydes is mediated by various Lewis acids.Threo isomers are the major diastereoisomers formed in most cases.A reverse diastereoselectivity was observed when the reaction was mediated by TBAF.The results have been discussed in detail by structure and transition state analysis.
The aldol reaction of the silyl enol ether of cyclopent-2-enone with aldehydes is mediated by various Lewis acids.Threo isomers are the major diastereoisomers formed in most cases.A reverse diastereoselectivity was observed when the reaction was mediated by TBAF.The results have been discussed in detail by structure and transition state analysis.
