摘要
回的:为了研究消化性溃疡患者粘膜生长抑素(SS)和精氨酸加压素(AVP)的分布及其在溃疡发病中的作用。方法:应用放射免疫分析法对39例消化性溃疡患者胃、十二指肠粘膜SS和AVP含量进行了测定,并以20例慢性浅表性胃炎(CSG)作对照。结果:十二指肠溃疡(DU)胃(体、窦分别为177.1±115.6,330.9±92.6Pg/mg)十二指肠粘膜SS含量(153.5±106.5Pg/mg)显著低于CSG(分别为288.8±181.1,559.9±381.5和252.7±152.9Pg/mg,P<0.05),而DU球部粘膜AVP含量(52.3±29.7Pg/mg)显著高于CSG(37.7±19.2Pg/mg)。GU与CSG组比较均无显著性。结论:①胃、十二指肠存在AVP样物质;②DU发生与粘膜SS、AVP分泌失调有关。
AIM The distribution of somatostatin(SS)and argovasopressin(AVP)in gastrointestinal mucosa and their roles in the pathogenesis of peptic ulcer were studied.METHODS The concentrations of SS and AVP were determined by means of radioimmunoassay in mucosa biopsied from fundus,antrum,and duodenal bulb in 24 duodenal ulcer(DU)and 15 gastric ulcer(GU)patients.Twenty patients with chronic superficial gastritis(CSG)were controled. RESULTS In DU group,SS concentration(Pg/mg wet tissue)in fundus(177.1±115.6),antrum(330.9±92.6),and duodenal bulb(153.5±106.5)was significantly decreased(P<0.05)compared with that in CSG(288.8±181.1 in fundus,559.9±381.5 in antrum,252.7±152.9 in duodenal bulb).In duodenal bulb of DU,the AVP content(52.3±29.7 Pg/mg wet tissue)was significantly higher than that in the control(37.7±19.2 Pg/mg wet tissue,P<0.05).But the results were not obtained in patients withGU(P>0.05)CONCLUSIONS Our results suggested that(1)SS and AVP are widely distributed from fundus to duodenal bulb mucosa in adult human subjects(2)Lower SS and higher AVP levels in the gastroduodenal mucosa were associated with the pathogenesis of DU.
出处
《世界华人消化杂志》
CAS
1994年第3期147-148,132-133,共4页
World Chinese Journal of Digestology
