摘要
目的探讨十二指肠溃疡（DU）伴幽门螺杆菌（Hp）相关性胃窦炎时生长抑素（SS）含量与D细胞超微结构变化。方法采用放免法测定52例活动期十二指肠溃疡及60例非溃疡对照组空腹血浆及胃窦粘膜组织中SS含量，同时应用免疫组化及免疫电镜分别于光镜和透射电镜下观察了粘膜组织中D细胞的数量和超微结构。结果42例Hp阳性DU患者，胃窦粘膜病理多呈中重度炎性变化；血浆及粘膜组织中SS含量显著降低（P＜0．01），D细胞数量显著减少（P＜0．01）。粗面内质网扩张，核糖颗粒脱失。结论由于Hp相关性胃窦炎的影响，DU患者胃窦D细胞数量上减少，合成和分泌SS功能亦降低。
Objective To explore the changes of Somatostatin(SS) contents and D cell ultrastructure in duodenal ulcer(DU) disease complicated with SS associated antral gastritis. Methods The fasting serum and antral mucosal SS were determined by radioimmunoassay in 52 patients with active DU (42 HP+) and 60 non-ulcer (24 HP+) controls. The counts and ultrastructure of antral somatostatin-producing D--cells were investigated by immunohistochemistry and observed by microscopy and transmission electron microscopy (TEM) simultaneously. Results in 42 Hp-positive DU patients, the antral mucosal biopsy showed moderate or severe inflammatory changes, the plasma and antral mucosal SS were significantly decreased, the D cell counts were also decreased quantitively. With TEM, cystiform dilated rough endoplasmic reticulum could be seen in D cells,ribosomes were detached, secretory granules were also decreased. Conclusion Owing to the influence of HP associated antral gastritis, antral D cells in patients not only showed decrease in quantity but also decrease in synthetic and
出处
《中华消化杂志》
CAS
CSCD
北大核心
1998年第5期281-283,共3页
Chinese Journal of Digestion
关键词
十二指肠溃疡
胃窦炎
幽门螺杆菌
生长抑素
电镜
Duodenal ulcer Antral gastritis Helicobacter pylori Somatostatin D cell TEM
