摘要
本实验选用大耳白兔59只,观察“平尔热”煎剂对内生性致热原(eudogenouspyrogen,EP)性发热的作用。实验分为4组:(1)空白对照组,(2)单纯平尔热组,(3)EP 性发热组,(4)EP 性发热+平尔热组。实验结果证实:单纯平尔热煎剂对家兔正常体温无明显影响。而家兔耳缘静脉注入0.5ml/kg 体重含 EP 上清后,60min 时体温上升最高,最大体温变化(ΔT)及4h 体温变化指数(TRI_4)远高于对照组,P 均<0.01。60min 时脑脊液(CSF)中环磷酸腺苷(cAMP)含量明显升高,与对照组相比有显著性差异,P<0.01。平尔热煎剂(20ml/kg 体重)能明显降低 EP 引起的发热效应及 CSF 中 cAMP 含量,同时60min 时ΔT及 TRI_4明显低于 EP 性发热组,P 均<0.01。提示平尔热煎剂可能通过某些途径引起中枢cAMP 的改变,从而抑制发热效应。
Endogenous pyrogen (EP) fever model was established by i.v.injected EP extract 0.5 ml/kg.59 Japanese white rabbits were divided into four groups.(1) Control group,(2) Ping Er Re (PER) group,(3) EP group. (4) EP+PER group.The effects of PER decoction on EP fever and cAMP concentration in CSF were observed. The results showed that (1) PER had no obvious effect on body temperature of normal rabbits.(2) Febrile re- sponse of EP was significantly inhibited by PER Decoction.(3) 60 rain after injection of EP,fever reached the peak point,and cAMP in CSF was 33.15±2.54cpm/ml,while the EP+PER group,febrile response and cAMP in CSF were obviously lower than that of EP group (P<0.01.P<0.05 respectively).The results suggested that PER might decrease the fever by inhibiting cAMP synthesis and its secretion in brain.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
1995年第S1期329-330,407,共3页
Chinese Journal of Integrated Traditional and Western Medicine
