摘要
本实验选用日本大耳白家兔５２只，观察了清开灵液对白细胞致热源（ｌｅｕｃｏｃｙｔｉｃｐｙｒｏ－ｇｅｎ，ＬＰ）性发热效应及脑脊液（ＣＳＦ）中ｃＡＭＰ含量变化的影响。结果显示：（１）清开灵液对家兔正常体温的影响与正常对照组相比没有明显的差异（Ｐ＞０．０５）。（２）单独注射ＬＰ引起直肠温度上升０．９３±０．２０℃（△Ｔ），体温反应指数（ＴＲＴ＿４）为１．９０±０．５１。ＬＰ＋清开灵组，静脉注射ＬＰ半小时前肌肉注射清开灵液，△Ｔ为０．４６±０．１４℃；ＴＲＩ＿４为０．８６±０．２１，与单独注射ＬＰ组比较差异非常显著（Ｐ＜０．００１），说明清开灵液有明显的解热作用。（３）静脉注射ＬＰ１ｈ时，检测兔ＣＳＦ中ｃＡＭＰ含量为２４．７５±３．７４ｐｍｏｌ／ｍｌ，而ＬＰ＋清开灵组ｃＡＭＰ含量为１８．２５±１．００ｐｍｏｌ／ｍｌ，两组相比差异非常显著（Ｐ＜０．０１）。同时发现清开灵液有使正常家兔ＣＳＦ中ｃＡＭＰ含量下降的趋势。各组体温变化与ＣＳＦ中ｃＡＭＰ含量变化呈显著正相关（ｒ＝０．９８４２，Ｐ＜０．０５）。本实验结果表明，清开灵液不仅抑制ＬＰ引起的发热反应，而且明显降低ＬＰ引起的ＣＳＦ中ｃＡＭＰ含量的增多。作者推论：清开灵液的?
Japanese white rabbits were used to study the effects of Qing Kai Ling(QKL )on leucocytic pyrogen( LP ) fever and cAMP concentration of cerebrospinalfluid (CSF).The results suggested that ( 1 ) The rectal temperature of normal rabbitswas not affected by QKL solution( P>0.05 ).(2 ) Febrile response of LP was signific-antly inhibited by QKL.(3 )cAMP concentration of CSF of the LP +QKL group inje-cting LP 1 hour after was obviously lower than that of LP group ( P<0.01).Andthere was a positive correlation between the cAMP level and the body temperaturechange(r=0.9842,P< 05).These results demonstrated that the increase of the bodytemperature and the cAMP concentration in CSF induced by LP were significantly inhi-bited by injected QKL solution.It was suggested that the mechanism of febrifugal effectof QKL solution might be associated with a drop of cAMP synthesis in hypothalamus.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1995年第1期54-57,共4页
Chinese Journal of Pathophysiology
关键词
发热
腺苷环-磷酸
清开灵液
脑脊液
Pyrogen
Fever
Adenosine cyclic monophosphate
Medical,Chinesetraditional
