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按(一级并行)米氏过程消除药物的稳态性质分析的数值解法 被引量:2

Numerical Method for the Analysis of the Properties of the Steady-State of the Plasma Concentration of Drugs Obeying Parallel First Order and Michaelis-Menten Clearance Kinetics
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摘要 本文讨论消除符合(一级并行)米氏过程药物的多剂量周期性血管外或血管内给药稳态性质分析的数值解法。 In this paper,we have proposed a numerical method to analyse the properties of the steady-state of the plssma concentration of drugs obeying parallel first order and Michaelis-Menten clearance kinetics,inputed by multiple extravenous or intravenous administration.
出处 《生物数学学报》 CSCD 北大核心 1996年第4期210-214,共5页 Journal of Biomathematics
关键词 药物动力学 给药方案 米氏消除 Pharmacokinetics,Dosage regimen,Michaelis-Menten clearance
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  • 1John T. Slattery. A pharmacokinetic model-independent approach for estimating dose required to give desired steady-state trough concentrations of drug in plasma[J] 1980,Journal of Pharmacokinetics and Biopharmaceutics(1):105~110 被引量:1
  • 2Ronald J. Sawchuk,Tom S. Rector. Steady-state plasma concentrations as a function of the absorption rate and dosing interval for drugs exhibiting concentration-dependent clearance: Consequences for phenytoin therapy[J] 1979,Journal of Pharmacokinetics and Biopharmaceutics(6):543~555 被引量:1

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