摘要
目的：通过与Ｔｃ－９９ｍ－ＭＤＰ显像的对比，评价Ｇａ－６７显像在淋巴瘤骨转移的临床价值。方法：６３例经ＣＴ，Ｘ线平片或组织活检证实淋巴瘤骨转移病人，１７例霍杰金氏淋巴瘤（ＨＬ），４６例非霍杰金氏淋巴瘤（ＮＨＬ），所有病人均行Ｇａ－６７和Ｔｃ－９９ｍ－ＭＤＰ全身骨扫描，其中４２例行化疗４个疗程后的Ｇａ－６７显像。静脉注射Ｇａ－６７３７０ＭＢｑ（１０ｍＣｉ）和７４０ＭＢｑ（２０ｍＣｉ）的Ｔｃ－９９ｍ－ＭＤＰ，分别在４８－７２小时和３－４小时后，进行前后位全身扫描。结果：６３例淋巴瘤骨转移的病人中，共有骨病灶１２８个。Ｇａ－６７显像诊断灵敏度为８９％，而Ｔｃ－９９ｍ－ＭＤＰ诊断灵敏度为９８％；Ｇａ－６７显像与Ｔｃ－９９ｍ－ＭＤＰ骨扫描对比发现有３１个病灶内Ｔｃ－９９ｍ－ＭＤＰ摄取高于Ｇａ－６７的摄取，而有２１个病灶内Ｇａ－６７摄取高于Ｔｃ－９９ｍ－ＭＤＰ的摄取。Ｇａ－６７显像对治疗反应的评价：随访中，在４２例治疗前Ｇａ－６７骨显像阳性者，Ｇａ－６７显像提示完全治愈的准确率为９１％；未治愈者，Ｇａ－６７显像还有Ｇａ－６７异常摄取。结论：６７Ｇａ显像可准确地判断淋巴瘤骨转移的疗效；对淋巴瘤骨转移的探测Ｔｃ－９９ｍ－Ｍ?
Objective: Evaluation of Ga-67 imaging in lymphoma with bone involvement was performed by the comparison with Tc-99m-MDP bone scan.Methods: In 63 patients with bone involvement of lymphoma proven by CT, X-rays or biopsy included 17 with Hodgkin's lymphoma(NL) and 46 with Non-Hodgkin's lymphoma(NHL), Ga-67 and'Tc-99m-MDP scintigraphy were performed after 48-72h of Ga-67 injection(10mCi) and 3-4h of Tc-99m-MDP injection(20 mCi) in all patients. of these, 42 patients were imaged after 4 cycles of chemotherapy. Results: In 63 patients total bone lesion is 128. The diagnostic sensitivity of Ga-67 and Tc-99m-MDP scintigraphy is 89 % and 98% respectively. The Tc-99m-MDP uptake is higher than Ga-67 in 31 bone lesions,but there are 21 bone lesions with higher Ga-67 uptake than Tc-99m-MDP.About monitoring therapy, accurate rate of Ga-67 imaging is 91%, the hare lesions with no remission were still have ab- normal uptake of Ga-67. Conclusion: Da-67 scintigraphy correctly monitored the response to treatment in patients with bone involvement of lymphoma; Detection rate of Tc-99m-MDP imaging was better than Ga-67 imaging in patients with bone involvement of lymphoma.
出处
《中国临床医学影像杂志》
CAS
2000年第S1期62-64,共3页
Journal of China Clinic Medical Imaging
关键词
99M锝美罗酸盐
淋巴瘤
肿瘤转移
technetium Tc 99m medronate
lymphoma
neoplasm metastasis,
