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原发性高血压治疗中贝尼地平的疗效与肾保护作用 被引量：3

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摘要 【目的】评价原发性高血压治疗中贝尼地平的临床疗效及肾脏保护作用。【方法】76例门诊一直服用氨氯地平的高血压病人,给予更换贝尼地平治疗。更换前、后均测量血压、心率、24h尿蛋白测定并计算尿蛋白/肌酐的比率。【结果】①更换前、后血压差别无显著性;②更换贝尼地平后1个月,24h尿蛋白量(232±69vs223±58;P>0.05)及尿蛋白/肌酐比率(227±53vs216±69;P>0.05)均有下降趋势,但差别无统计学意义③贝尼地平联合ARB或ACEI治疗前后24h尿蛋白量(254±47vs205±62;P<0.05)及尿蛋白/肌酐比率(236±44vs188±56;P<0.05),差别有统计学意义。【结论】贝尼地平的降压效果与氨氯地平相当,而在降低尿蛋白方面则有优于氨氯地平的趋势;贝尼地平联合ARB或ACEI对肾脏有明显保护作用。
作者 郑东诞 高修仁 陈宏武 曾群英 王强 梅卫义
机构地区 中山大学附属第一医院心血管内科 中山大学附属第一医院急诊科
出处 《中山大学学报（医学科学版）》 CAS CSCD 北大核心 2008年第S1期149-151,共3页 Journal of Sun Yat-Sen University:Medical Sciences
关键词 原发性高血压 盐酸贝尼地平 苯磺酸氨氯氮平
分类号 R544.1 [医药卫生—心血管疾病]
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参考文献11

  • 1康连鸣,李一石,胡大一,郭静萱,张麟,黄洁,汪芳,边文彦,王力.盐酸贝尼地平治疗原发性高血压的多中心临床研究[J].中国临床药理学杂志,2005,21(1):3-7. 被引量：14
  • 2Wang T,,Takabatake T.Effects of vasopeptidase inhibition on renal function and tubuloglomerular feedback in spontaneously hypertensive rats. Hypertension Research . 2005 被引量：1
  • 3Mitsuru OHISHI,Takashi TAKAGI,Norihisa ITO,et al.Renal-protective Effect of T-and L-Type calcium channel blockers in hypertensive patients:an Amlodipine-to-Benidipine changeover(ABC)study. Hypertension Research . 2007 被引量：1
  • 4Brenner BM,Cooper ME,Zeeuw DD,et al.Effects of losartan on renal and cardiovascular outcomes in patients with Type 2 diabetes and nephropathy. New England Journal of Homeopathy . 2001 被引量：1
  • 5Peterson J C,Adler S,Burkart J M,et al.Blood pressure control, proteinuria, and the progression of renal disease.The Modification of Diet in Renal Disease Study. Annals of Internal Medicine . 1995 被引量：1
  • 6De,Leeuw,PW,Thijs,L,Birkenhager,WH.Prognostic significance of renal function in elderly patients with isolated systolic hypertension: results from the Syst-Eur trial. Journal of the American Society of Nephrology . 2002 被引量：1
  • 7Marin R,Gorostidi M,Fernandez-Vega F,et al.Systemic and glomerular hypertension and progression of chronic renal disease: the dilemma of nephrosclerosis. Kidney International Supplement . 2005 被引量：1
  • 8Hayashi K,Wakino S,Homma K,et al.Pathophysiological significance of T-type Ca2+channels:role of T-type Ca2+channels in renal microcirculation. Journal of Pharmacological Sciences . 2005 被引量：1
  • 9Ruggenenti,P,Perna,A,Loriga,G.Blood-pressure control for renoprotection in patients with non-diabetic chronic renal disease (REIN-2): multicentre, randomised controlled trial. The Lancet . 2005 被引量：1
  • 10Furukawa,T.,Yamakawa,T.,Midera,T.Selectivities of dihydropyridine derivatives in blocking Ca2+ channel subtypes expressed in Xenopus oocytes. J. Pharmacol. Exp. Therapy . 1999 被引量：1

二级参考文献4

  • 1Ishii A,Toyama J.Binding properties of ( +/- ) [3H] benidipine hydrochloride to rat heart membranes [J].J Cardiovasc Pharmacol,1993 ;21:191-196. 被引量：1
  • 2Karasawa A,Kubo K.Calcium antagonistic effects and the in vitro duration of actions of KW-3049,a new 1,4-dihydropyridine derivative,in isolated canine coronary arteries [J].Jpn J Pharmacol,1988; 47: 35-44. 被引量：1
  • 3Nakajima O,Akioka H,Miyazaki M.Effects of the calcium antagonist benidipine hydrochloride on 24-h ambulatory blood pressure in patients with mild to moderate hypertension in a double-blind study against placebo [J].Arzneim-Forsch,2000 ;50:620-625. 被引量：1
  • 4Saruta T,Kubo K.A study of benidipine hydrochloride in hypertensive patients with renal impairment in long -term treatment[J].Therapeutic Res,1998; 19:361-365. 被引量：1

共引文献13

同被引文献36

  • 1张维忠.新型钙拮抗剂贝尼地平基础与临床研究进展[J].高血压杂志,2005,13(4):196-197. 被引量：33
  • 2Chien KL,Su TC,Jeng JS,et al.Carotid artery intima-medis thickness,carotid plaque and coronary heart disease and stroke in Chinese.PLoS One,2008,3(10):e3435. 被引量：1
  • 3Hodis HN,Mack WJ,La Bree L,et al.The role of carotid arterial intima-media thickness in pridicting clinical coronary events.Ann Inter Med,1998,15(128):262-269. 被引量：1
  • 4O'Leary DH,Polak JF,Kronmal RA,et al.Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults.Cardiovascular Health Study Collaborative Research Group.N Engl J Med,1999,340(1):14-22. 被引量：1
  • 5Sahoo R,Krishna MV,Subrahmaniyan DK,et al.Common carotid intima-media thickness in acute ischemic stroke:a case control study.Neurol India,2009,57 (5):627-630. 被引量：1
  • 6Lee YH,Kweon SS,Choi JS,et al.Association of blood pressure levels with carotid intima-media thickness and plaques.J Prey Med Public Health,2009,42(5):298-304. 被引量：1
  • 7Bonithon-Kopp C,Ducimetere P,Touboul PJ,et al.Plasma angiotensin-converting enzyme activity and carotid wall thickening.Circulation,1994,89 (3):952-954. 被引量：1
  • 8Langenfeld MR,Forst T,Hohberg C,et al.Pioglitazone decreases carotid intima-media thickness independently of glycemic control in patients with type 2 diabetes mellitus:results from a controlled randomized study.Circulation,2005,111 (19):2525-2531. 被引量：1
  • 9Reis KA,Guz G,Ozdemir H,et al.Intravenous iron therapy as a possible risk factor for atherosclerosis in end-stage renal disease.Int Heart J,2005,46(2):255-264. 被引量：1
  • 10Meruri M,Bond MG,Sirtori CR,et al.Pravastatin reduces caritid intima-media thickness progression in an asymptomatic hypercholesterolernic mediterranean population:the Carotid Atherosclerosis Italian Ultrasound Study.Am J Med,1996,101 (6):627-634. 被引量：1

引证文献3

二级引证文献9

中山大学学报（医学科学版）
2008年 第S1期

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