期刊文献+

乔木茵芋中黄酮和生物碱类化合物及其镇痛活性研究 被引量:4

Studies on flavonoid and alkaloid from Skimmia arborescens Anders. ex Gamble and its pain releasing effect
原文传递
导出
摘要 对乔木茵芋进行化学成分研究.采用硅胶柱色谱、葡聚糖凝胶LH-20柱色谱、RP-C18柱色谱等方法分离化学成分,1H NMR、13C NMR等方法进行结构鉴定,从中分离鉴定了5个黄酮类化合物:槲皮素(1),槲皮苷(2),山奈酚-3,7-葡萄糖苷(3),枸橘苷(4),橙皮苷(5);1个生物碱类化合物:1-甲基-2-苯基-4-喹啉酮(6).所有化合物均为首次从该种植物中分离得到.并采用小鼠醋酸扭体法和热板法检测乔木茵芋总提取物及乔木茵芋总生物碱提取物的镇痛活性.结果显示乔木茵芋总提物和乔木茵芋总生物碱提取物均可明显抑制醋酸所致小鼠扭体反应,此外乔木茵芋总生物碱提取物还可明显提高小鼠对热刺激的痛阈值,具有较好的镇痛活性. To study the chemical constituents of Skimmia arborescens. The chemical constituents were isolated by silica gel column chromatography, Pharmadex LH - 20, RP - C18, and the ^1H NMR, ^13 C NMR spectroscopic analysis were employed for the structural elucidation. Six Compounds were isolated from Skimmia arborescens. Their structures were elucidated as quercetin ( 1 ), quercetin 3 - O - α - L - Rha ( 2 ), kaempferol - 3,7 - o -β - D - glucosides ( 3 ), poncirin (4), hesperidin ( 5 ), 1 - methyl - 2 [ (Z) - 7 - phenyl ] - 4 ( 1 H ) - quinolone ( 6 ), The 6 compounds were isolated from the plant for the first time. Using acetic acid writhing and hot plate test in mice, the pain releasing effects of the total extract and the total alkaloids from the plant were evaluated. The results indicated that both the total extract and total alkaloids of Skimmia arborescens could markedly decrease mice writhing caused by acetic acid. Furthermore, the total alkaloid of Skimmia arborescens could extend evidently pain threshold in mice.
出处 《云南大学学报(自然科学版)》 CAS CSCD 北大核心 2011年第6期705-709,共5页 Journal of Yunnan University(Natural Sciences Edition)
基金 云南省科研院所技术开发研究专项(2004KFZX-12)资助
关键词 乔木茵芋 黄酮 生物碱 镇痛活性 Skimmia arborescens flavonoids alkaloid pain releasing effect
  • 相关文献

参考文献16

  • 1张洪杰,管宁宁,张明哲.多脉茵芋中挥发油化学成分的研究[J].北京大学学报(自然科学版),1996,32(2):135-139. 被引量:7
  • 2PATHAK H D, PANT J N. Chemical examination of Skimmia laureola[ J ]. Indian Perfumer Dep. Chem. , D. S. B. Gov. Coll. , Nainital, India, 1972,16 ( 1 ) :45-51. 被引量:1
  • 3ATKINSON E, BOYD D R, GRUNDON M F. Coumarins of Skimmia japonica [ J ]. Phytoehemistry ( Elsevier), 1974,13 (5) : 853 -855. 被引量:1
  • 4WU Tian-shung. Alkaloids and coumarins of Skimmia reevesiana [ J ]. Phytochemistry, 1987,26 ( 3 ) : 873-875. 被引量:1
  • 5Nakatani Munehiro, Ishiba Keiichi, Fujimoto Koichi, et al. Coumarins and triterpenes from Skimmia japonica Thunb [ J ]. Kago- shima Daigaku Rigakubu Kiyo, Sugaku, Butsurigaku, Kagaku, 1991,24:81-86. 被引量:1
  • 6Sharma Rajni Kant, Negi Poonam, Negi Nisha, et al. New coumarin from Skimmia anquetelia[J]. Journal of the Indian Chemi- cal Society,2008,85 (10) :1 055-1 056. 被引量:1
  • 7Sultana Nighat,Afza Nighat,Atta- ur- Rahman. Coumarin and quinoline alkaloids from Skimmia laureola[ J]. Science Inter- national ( Lahore, Pakistan), 2004,16 (4) :271-274. 被引量:1
  • 8Atta - ur - Rahman, Sultana Nighat, Khan M Riaz, et al. Triterpene and coumarins from Skimmia laureola[ J ]. Natural Product Letters, 2002,16 (5) : 305-313. 被引量:1
  • 9Sultana Nighat, Atta - ur - Rahman, Khan Tariq H. Tyrosinase inhibitor fatty ester and a quinoline alkaloid from Skimmia laureola [ J ]. Zeitschrift fuer Naturforschung B : Chemical Sciences ,2005,60 ( 11 ) : 1 186-1 191. 被引量:1
  • 10陈奇主编..中药药理研究方法学 第2版[M].北京:人民卫生出版社,2006:1204.

二级参考文献75

共引文献93

同被引文献50

引证文献4

二级引证文献11

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部