摘要
目的探讨老年慢性心力衰竭(CHF)患者血浆脑钠肽前体(NT-proBNP)水平与左室功能的关系及临床意义。方法将93例老年CHF患者按美国心脏病协会(NYHA)分级方法分为心功能Ⅱ、Ⅲ、Ⅳ级3组,25名健康老年人纳入对照组。采用电化学发光免疫分析技术测定4组血浆NT-proBNP水平,用超声心动图测定左室舒张末期内径(LVEDD)和左心室射血分数(LVEF)。结果心力衰竭NT-proBNP、LVEDD显著高于对照组(P<0.01),且血清NT-proBNP浓度随着心功能分级的增加而升高(3组两两比较均有统计学意义,P<0.01)。NT-proBNP水平与LVEDD呈正相关(r=0.711,P<0.01),而与LVEF呈负相关(r=-0.85,P<0.01)。结论血浆NT-proBNP水平可作为CHF患者心功能检测的有效生化指标,可以用来评估老年心力衰竭患者的左室功能。
Objective To investigate the relationship between the level of serum N-terminal pro-brain natriuretic peptide（NT-proBNP）and left ventricular function in elderly patients with chronic heart failure（CHF）and the clinical significance.Methods The 93 patients with CHF were divided into 3 CHF groups according to NYHA and 25 healthy elderly subjects were enrolled in control group.The serum level of NT-proBNP were measured by electrochemiluminescent immunoassay（ECLIA）,and left ventricular ejection fraction（LVEF）and left ventricular end diastolic diameter（LVEDD）was detected by echocardiograph.Results The NT-proBNP levels in CHF groups were significantly higher than that of control group（P0.01）.Furthermore,the NT-proBNP level increased gradually with increased NYHA cardiac functional grade by degree.（each other had significant difference,P0.01）,and correlated positively with LVEDD（r=0.711,P0.01）as well as correlated negatively with LVEF（r=-0.85,P0.01）.Conclusion The serum level of NT-proBNP is thought as a valid biochemical marker to evaluate left ventricular function in CHF of elderly patients.
出处
《实用心脑肺血管病杂志》
2011年第12期2035-2036,共2页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
心力衰竭
充血性
心室功能
左
超声心动描记术
Heart failure
congestive
Ventricular functioneft
left
Echocardiography
