摘要
目的评价榄香烯乳注射液联合FOLFOX 4方案治疗晚期胃癌的临床疗效和不良反应。方法 49例晚期胃癌随机分为榄香烯乳注射液联合化疗(治疗组)25例和单纯化疗(对照组)24例,两组均应用FOLFOX 4方案(奥沙利铂85mg/m2静滴,第1天;亚叶酸钙50mg静滴,第1、2天;氟尿嘧啶400mg/m2静推,600mg/m2静脉持续滴注22h,第1、2天;2周为1周期)化疗,治疗组同时加用榄香烯乳注射液(500mg静滴,2周为1周期),治疗4周期后比较两组的疗效及毒副反应。结果治疗组获CR 3例,PR 12例,有效率(RR)为60.0%;对照组获CR 2例,PR 8例,RR为41.7%,两组差异有统计学意义(P<0.05)。治疗组和对照组的中位疾病进展时间(TTP)分别为7.1个月和5.2个月,中位生存时间(OS)分别为11.0个月和9.3个月,两组差异均有统计学意义(P<0.05)。治疗组中性粒细胞减少、恶心呕吐、腹泻发生率均低于对照组(P<0.05)。治疗组Karnofsky评分提高为48%,高于对照组的25%(P<0.05)。结论榄香烯乳注射液能够有效提高FOLFOX 4方案治疗晚期胃癌的疗效,减轻其不良反应,改善患者的生存质量并延长生存时间。
Objective To evaluate the efficacy and adverse reactions of elemene emulsion combined with FOLFOX 4 regimen in the treatment of advanced gastric cancer.Methods Forty-nine patients were randomly divided into treatment group（n=24） and control grouip（n=25）.Both the two groups were treated by FOLFOX 4 regimen（oxaliplatin 85mg/m2 iv,d1;leucovorin 50mg iv,d1,d2;fluorouracil 400mg/m2 iv,600mg/m2 civ 22h,d1,d2;2 weeks was a cycle）,and treatment group was also given elemene emulsion（500mg iv,2 weeks was a cycle）.The efficacy and adverse reactions were evaluated after four cycles.Results The response rate were 60.0%（CR 3 cases,PR 12 cases） in treatment group and 41.7%（CR 2 cases,PR 8 cases） in control group respectively（P0.05）.The median time to progression in treatment group and control group were 7.1 months versus 5.2 months（P0.05） and median overall survival were 11.0 months versus 9.3 months（P0.05）.A lower rate of leucopenia,nausea,vomiting and diarrhea occurred in treatment group compared with that of control group（P0.05）,and there was significant difference in the elevation of life quality（48% vs.25%） as well（P0.05）.Conclusion Elemene emulsion combined with FOLFOX 4 regimen can improve the efficacy,decrease the incidence of side effects of chemotherapy,elevate the life quality and prolong the survival in advanced gastric cancer.
出处
《临床肿瘤学杂志》
CAS
2011年第10期917-919,共3页
Chinese Clinical Oncology
基金
常州市卫生创新人才培养工程资助项目(常卫科教[2010]368号)
