摘要
目的:评估TLR4与肿瘤发病的关系,并探讨其在肿瘤治疗中的作用。方法:以"TLR4、肿瘤(tumor)"为关键词,使用PubMed和CNKI数据库对2005-01-2010-12发表的文章进行分别和联合检索。纳入标准:1)TLR4的基本资料介绍;2)TLR4在肿瘤组织中的表达研究;3)TLR4在肿瘤治疗中的作用。根据纳入标准分析43篇文献。结果:TLR4的在胃癌、B细胞淋巴瘤、肝细胞癌、结肠癌、膀胱癌和前列腺癌等多种恶性肿瘤组织及细胞中阳性表达。TLR4是把双刃剑,一方面促进肿瘤的发展,另一方面对某些肿瘤的生长起抑制作用。结论:TLR4及TLR4的寡核苷酸基因多态性与肿瘤发生发展密切相关。TLR4有望成为肿瘤治疗的新靶点。
OBJECTIVE：To evaluate the relationship between TLR4 and cancer incidence and investigate the clinical significance of TLR4 as a target for cancer therapy. METHODS： PubMed and CNKI were searched with the key words of “LR4”and “umor”from January 2005 to December 2010. Choice criteria： 1）the characteristics of TLR4. 2）the expression of TLR4 in tumors. 3）role of TLR4 for tumor therapy. Totally 43 papers were selected. RESULTS：TLR4 is expressed in some tumors such gastric cancer, B-cell lymphoma, hepatocellular carcinoma, colon, bladder, and prostate cancer. TLR4 is a double-edged sword. On the one hand, TLR4 promotes tumor development, on the other hand, TLR4 restrains tumor growth in some of the body. CONCLUSION： More and more evidences indicate that the expression of TLR4 and the polymorphism gene of TLR4 are associated with tumor progression, and TLR4 is expected to be a promising target for the anticancer treatment in the future.
出处
《中华肿瘤防治杂志》
CAS
2011年第17期1412-1416,共5页
Chinese Journal of Cancer Prevention and Treatment
基金
山东省科技攻关计划项目(2008GG2NS02017)
关键词
受体
细胞表面
肿瘤
治疗
综述文献
receptors cell surface neoplasms therapy review literature
