摘要
【目的】研究血管内皮生长因子受体 3(VEGFR 3)在非小细胞肺癌 (NSCLC)癌组织的表达 ,以探讨VEGFR 3与NSCLC不同类型、TNM分期和预后的关系。【方法】收集手术切除的NSCLC癌组织标本 5 0例 ,以同期肺炎性假瘤组织标本 2 0例作为对照组 ,应用免疫组化方法检测标本中VEGFR 3的表达情况。【结果】①NSCLC的VEGFR 3阳性表达率为 6 0 .0 % ,对照组VEGFR 3的阳性表达率为 10 .0 % ,两者间比较存在显著性差异 (P <0 .0 5 )。②VEGFR 3的阳性率随着肺癌TNM分期增加而增高 ,Ⅰ期与Ⅲa期、Ⅲb期肺癌之间有统计学差异 (P <0 .0 5 ) ;Ⅱ期肺癌与Ⅲb期相比较有统计学差异 (P <0 .0 5 )。③VEGFR 3表达阳性的NSCLC患者的生存时间与VEGFR 3表达阴性NSCLC患者的生存时间有显著性差异。【结论】NSCLC组织中VEGFR 3的表达与NSCLC的TNM分期和预后有关 ,可作为评估NSCLC患者预后的指标。
Objective To investigate the expression of vascular endothelial growth factor receptor-3 (VEGFR-3) in tissues of non-small cell lung cancer.(NSCLC) and explore the relationship of VEGFR-3 to the different types, stage in tumor node metastasis (TNM) and prognosis of NSCLC.The expressions of VEGFR-3 in surgically resected tumor specimens collected from 50 cases with NSCLC and pulmonary inflammatory pseudotumor specimens from 20 cases served as controls were detected by immunohistochemical method.①The positive expression rate of VEGFR-3 in NSCLC (60%) was significantly higher than that in control group (10.0%)(P<0.05). ②The elevation of positive VEGFR-3 expression accompanied the increase of TNM stage, there were statistical differences between I and Ⅲa stage(P<0.05)as well as Ⅰ and Ⅲb stage of lung cancers(P<0.05), also statistical difference was found between its Ⅱ and Ⅲb stage(P<0.05). ③The NSCLC patients with positive expression of VEGFR-3 protein had a markedly shorter survival time than those with negative expression.[Conclusion]The expression of VEGFR-3 in tumor tissues of NSCLC is correlated with its TNM stage and prognosis. VEGFR-3 detection can be used as a criterion for evaluation of prognosis in NSCLC patients.
出处
《医学临床研究》
CAS
2004年第7期753-755,共3页
Journal of Clinical Research
关键词
癌
非小细胞肺
内皮生长因子
受体
细胞表面
carcinoma,non-small-cell lung
endothelial growth factors
receptors,cell sufface
