摘要
丝裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)对于细胞的生长、分裂、分化和凋亡具有重要的调节作用。脑胶质瘤是一种严重危害人类健康的颅内恶性肿瘤,具有发病率和病死率高的特点。近年来的研究发现,MAPK信号通路在脑胶质瘤等多种恶性肿瘤组织中发生了活性改变,同时MAPK又介导了多种药物的抗肿瘤作用。本文对MAPK与脑胶质瘤的关系进行简要综述。
Mitogen-activated protein kinase（MAPK） plays an important role in the regulation of cellular growth,fission,differentiation and apoptosis.Glioma is an intracranial malignant tumor,which is severely threatening the human health.This malignant tumor is characterized by high incidence and mortality.Recently,it has been shown in many reports that there is a change in the activity of MAPK signaling pathway in various malignant tumors such as glioma,and MAPK can mediate the antitumor properties of many drugs.This article reviews the relationship between glioma and MAPK.
出处
《肿瘤》
CAS
CSCD
北大核心
2011年第9期871-874,共4页
Tumor
基金
国家自然科学基金资助项目(编号:30740027
30471778)
