摘要
目的:观察国产生长抑素注射液治疗肝硬化门静脉高压食管胃底静脉曲张急性出血的疗效。方法:选择104例肝硬化食管胃底静脉曲张急性出血患者,随机分成2组,治疗组56例,给予生长抑素(双鹭药业)治疗,对照组48例,给予善宁治疗,2组均配合给予奥美拉唑静脉滴注辅助治疗。结果:2组治疗后生命体征如心率、收缩压、舒张压、尿量以及患者的恶心、头晕、心悸、出汗、口渴症状均明显改善(P<0.05),治疗第24、48、72h和停药后24h,2组呕血次数和呕血量、黑便次数和黑便量均显著减少,组内比较均有显著的统计学差异(P<0.05),总有效率治疗组为96.4%,对照组为95.8%,2组间比较无统计学差异(P>0.05)。结论:国产生长抑素治疗肝硬化门静脉高压食管胃底静脉曲张出血的疗效与善宁相当。
Objective： To observe the therapeutic effect of homemade somatostatin in treatment of patients with acute gastroesophageal variceal bleeding due to hepatocirrhosis with portal hypertension.Methods： One hundred and four patients with acute gastroesophageal variceal bleeding were randomly divided into treatment group （n=56） and control group （n=48）. Patient were treated with homemade somatostatin or Sandostatin respectively, while all the patients were given Omerazole intravenously for auxiliary treatment. Results： Patients′ vital signs （heart rate, diastolic and systolic blood pressure, urine）, symptoms of nausea, dizziness, palpitation, sweating, thirst were all improved significantly in two groups （P0.05）. The frequency and quantity of hematemasis and melena were significantly decreased in 2 groups 24, 48, 72 hours after treatments and 24 hours after withdrawal of treatments. The total response rate of treatment group and control group were 96.4% and 95.8% respectively （P0.05）, there was no statistic difference between 2 groups（P0.05）. Conclusion： The efficacy of homemade somatostatin is similar to that of Sandostatin in treatment of acute gastroesophageal variceal bleeding.
出处
《内科急危重症杂志》
2011年第5期287-289,共3页
Journal of Critical Care In Internal Medicine
关键词
生长抑素
善宁
食管胃底静脉曲张出血
肝硬化
Somatostatin Octreotide Gastroesophageal variceal bleeding Hepatocirrhosis
