摘要
目的:观察国产生长抑素治疗重症急性胰腺炎的临床疗效及其对血浆内毒素和肿瘤坏死因子(TNF-α)水平的影响。方法:35例重症急性胰腺炎患者使用生长抑素治疗7～10d后,观察患者的症状、体征变化,血尿淀粉酶、肝功能恢复以及血浆内毒素和TNF-α水平等。结果:经过7～10d生长抑素治疗后,患者的症状、体征、血尿淀粉酶、肝功能以及血浆内毒素和TNF-α水平均得到不同程度的恢复,总有效率为84%。结论:国产生长抑素可以有效地控制重症急性胰腺炎的临床症状,迅速降低血浆内毒素和TNF-α水平,降低患者的死亡率和不良反应发生率。
Objective ：To observe the clinical effect of indigenous somatostatin on treatment of severe acutepancreatitis （SAP）and its effect on the level of plasma endotoxin and TNF-alpha. Methods： Symptoms,signs,serum -urine amylase, liver function,plasma endotoxin and TNF-alpha were observed in 35 patients with SAP after 7~10 d treatment with indigenous somatostatin.Results：Afer the 7-10 d treatment with indigenous somatostatin, the symptoms,signs,serum-urine amylase,liver function,plasma endotoxin and TNF-alpha of patients were found to have different improvement . The overall effective rate of somatostatin was 84%.Conclusion：Indigenous Somatostain may control the clinical symptoms of SAP, decrease the level of plasma endotoxin and TNF-alpha significantly and reduce the mortality and the occurance rate of adverse reactions.
出处
《中国医药导报》
CAS
2007年第07X期9-10,共2页
China Medical Herald
