摘要
目的探讨肾混合性上皮间质肿瘤(MESTK)的临床病理特点、鉴别诊断和生物学行为。方法报道3例MESTK的临床、病理组织学及免疫表型并复习相关文献。结果 3例MESTK中,男性2例,女性1例;均表现为肾区肿块,无肉眼血尿,其中1例有肾区疼痛。肿块大体均呈囊实性,切面灰白、灰黄色,质韧。镜下见上皮和间质成分,上皮可围成小管状或囊腔样;间质成分为不同形态的梭形细胞,异型性不明显,核分裂象少见,可呈束状平滑肌样或卵巢样排列;其中1例PR(+)。结论肾混合性上皮间质肿瘤较少见,具有上皮和间质两种成分,是一种独立的肾肿瘤,诊断主要依靠组织病理学和免疫组化标记,由于近年来出现复发病例和恶性病例报道,其生物学行为有待进一步观察。
Objective To study the clinical and pathological features,differential diagnosis and biological behavior of mixed epithelial and stromal tumor of the kidney（MESTK）.Methods Three cases of MESTK were clinically,histopathologically and immunohistochemically investigated with review of the relative literatures.Results Three patients were two male and one female.All of them presented an abdominal mass without hematuria and one with flank pain.Grossly,the tumors had solid and cyst appearance with a gray cut surface and tough texture.Microscopically,the tumors were composed of an admixture of epithelial and stromal elements： the epithelial component was composed of tubular and cystic spaces;the mesenchymal element was composed of solid spindle cells with variable cellularity but hardly atypia or nuclear fission and resemble bundles of smooth muscle or ovarian-like appearance.One case presented PR positive reaction.Conclusions MESTK is a rare neoplasm composed of epithelial and stromal elements and an independent entity and the diagnosis is determined by histopathology and immunohistochemistry.Because more and more malignant cases and recurrences are reported,further studies are needed to elucidate its bioligical nature.
出处
《诊断病理学杂志》
CSCD
2011年第5期341-343,共3页
Chinese Journal of Diagnostic Pathology
关键词
肾
混合性上皮间质肿瘤
临床病理学
免疫组化
Kidney
Mixed epithelial and stromal tumor
Clinicopathology
Immunohistochemistry
