摘要
目的:研究取代度为6.7的羟丙基-β-环糊精对难溶性药物依托泊苷的包埋特性。方法:采用红外分光光度法、差示扫描量热法、X-射线衍射法对包合物进行了研究。结果:羟丙基-β-环糊精与依托泊苷形成了1∶1的包合物,提高依托泊苷在水中的溶解度约75.1倍。结论:本实验的研究内容在提高药物的溶解度、稳定性和生物利用度等方面有广阔前景。
Objecfive：Hydroxypropyl-β- cyclodextrins of substituted degree of 6. 7 was investigated the complex forming capability by etoposide. Method： The inclusion complex was generated by IR, DSC and XRD. Results： Etoposide was formed a 1 ： 1 molar ratio inclusion complex with hydroxypropyl -β- cyelodextrins and improved solubility about 75.1 times. Conclusion： The experimental research has broad prospect on improving drug solubility, stability, bioavailability and so on.
出处
《药物分析杂志》
CAS
CSCD
北大核心
2011年第11期2103-2107,共5页
Chinese Journal of Pharmaceutical Analysis
