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基质金属蛋白酶-1、转录调节因子Ets-1与肿瘤关系的研究进展 被引量:2

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摘要 在肿瘤发生发展过程中,侵袭与转移是其最主要的生物学特征之一,也是肿瘤药物的作用靶点之一。在此过程中,基质金属蛋白酶(MMPs)在降解基底膜(BM)和细胞外基质(ECM)中发挥重要作用,可促进肿瘤侵袭和转移。Ets-1作为转录调节因子和肿瘤的发生发展也密切相关。本文仅对MMPs家族中的MMP-1及其关联因子Ets-1与肿瘤关系的研究进展进行简要综述。
出处 《山东医药》 CAS 北大核心 2011年第40期115-116,共2页 Shandong Medical Journal
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