摘要
目的:探讨促进脑静脉回流对急性动脉硬化性脑梗死患者脑功能及炎症因子的影响,为临床治疗提供参考。方法:急性动脉硬化性脑梗死40例作为观察组,健康体检者40例作为观察组,观察组患者采用基于溶栓的促进脑静脉回流治疗措施,观察两组治疗前后的sICAM-1、sVCAM-1和hs-CRP炎性标志物变化水平。结果:观察组患者治疗前sICAM-1、sVCAM-1和hs-CRP炎性标志物明显高于对照组,差异有统计学意义(P<0.05)。经过促进脑静脉回流措施治疗后,治疗脑功能好转28例,无脑功能好转12例,Logistic回归分析提示hs-CRP活性是临床转归的独立炎性标志物(P<0.05)。结论:促进脑静脉回流对急性动脉硬化性脑梗死治疗能改善脑功能,同时使相关炎症因子发生变化,其中hs-CRP活性从某种程度对脑梗死预后有提示作用。
Objective： To explore effect of promoting cerebral venous return on brain function and inflammatory factor of patients with acute arteriosclcrosis cerebral infarction for the rcferencc in clinical treatment.Methods： Forty patients with acute arteriosclerosis cerebral infarction were taken as Observatgon Group and healthy examined people as Control Group. Observation Group was treated with thrombolysis-bascd therapy promoting cerebral venous return. Please observe variations in sICAM-I, sVCAM-I and hs-CR inflammatory markers of both groups before and after treatment.Results： After therapy promoting ccrebral venous return, 28 cases＇ brain function took a turn for the better and I2 cases not. Logistic regression analysis showed hs-CRP activity wss an indcpendcnl inflammatory marker of efficacy of clinical prognosis （P〈0.05）.Conclusion：tt improved brain function of patients with acmc arteriosclerosis cerebral infarction and changed the inflammatory factor by promoting ccrebrat venous return. Hereinto, hs-CRP activity gave a hint at cerebral infarction to a certain degree.
出处
《中国医药导刊》
2011年第8期1395-1396,1393,共3页
Chinese Journal of Medicinal Guide
关键词
促进脑静脉回流
脑动脉硬化
脑梗死
脑功能
炎症因子
Promoting Cerebral Venous Return
Cerebral Arteriosclerosis
Cerebral Infarction
Brain Ftmction
Inflammatory Factor
