摘要
目的:探讨奥美拉唑与枸橼酸莫沙必利联用治疗功能性消化不良临床效果。方法:H.pylori感染引起的功能性消化不良140例根据入院顺序患者平分为两组-治疗组与对照组各70例,两组同时给予阿莫西林、克拉霉素治疗,在此基础上,治疗组给予奥美拉唑与枸橼酸莫沙必利联用治疗,对照组单独应用奥美拉唑治疗。结果:经过治疗后,治疗组的总有效率为85.7%,对照组的总有效率为71.4%,治疗组的临床总有效率明显高于对照组,差异有显著性(P<0.05)。同时治疗组与对照组H.pylori根除率分别为89.3%(62/70)和71.4%%(50/70),治疗组的H.pylori根除率明显高于对照组(P<0.05)。两组不良反应对比相似,多为轻、中度,可耐受,停药后自行消失。结论:奥美拉唑与枸橼酸莫沙必利联用治疗功能性消化不良疗效好,可提高H.pylori根除率,不良反应少,值得推广应用。
Objective： To exptorc clinical effect of omcprazolc and mosapridc citiate combined therapy in H.pylori infection induced functional dyspepsia.Methods： One hundred and forty patients with funclional dyspepsia were equally divided into Treatmenl Group and Control Group （each 70 cases）. Both wcrc treated with amoxicillin and clarithromycin. On the basis. Treatment Group was treated with combined therapy of omeprazolc and mosapride; Control Group was treated with only omeprazole,Results： Through treahnent. Treatment Group showed an overall effective rate of 85.7% and Comrol Group 71.4% （the former much higher）, with a significant difference （P〈0.05）. Meanwhile, H.phlori cradication rates of both groups were 89.3% （62/70） and 714%% （50/70） with the former much higher than the latter （P〈0.05）. And both groups showed similar umoward cflecls mainly including slight and intermediate tolerable effects. However, these effects sanished after drug withdrawal.Conclusion：It is effective to use omcprazolc and mosapride citrate combined therapy in H.pylori infection induced Ihnctional dyspepsia with the resuh of improving H.pylori eradication rate. having few untoward effects. For this reason., its application is worth promoting.
出处
《中国医药导刊》
2011年第8期1361-1362,共2页
Chinese Journal of Medicinal Guide
