摘要
目的:观察小剂量奥美拉唑治疗功能性消化不良(FD)的临床疗效,探讨其临床意义。方法:将2010年3月～2011年3月在我院接受治疗的252例FD患者随机分为奥美拉唑组和莫沙必利组,奥美拉唑组给予小剂量奥美拉唑口服治疗,莫沙必利组给予莫沙必利口服治疗,观察两组治疗前后反酸、饱胀、上腹痛/不适积分情况、临床疗效及不良反应情况,并进行对比分析。结果:两组患者在治疗后反酸、饱胀、上腹痛/不适积分均较治疗前有显著下降,组内比较差异均有统计学意义;奥美拉唑组治疗后的反酸、上腹痛/不适积分明显低于莫沙必利组,组间比较差异有统计学意义(P<0.05);奥美拉唑组有效率高达94.44%,明显高于莫沙必利组的75.60%,组间比较差异有统计学意义(P<0.05);两组患者均未发现明显的不良反应。结论:小剂量奥美拉唑治疗FD能明显改善胃部烧灼感及腹痛感,临床疗效肯定,且具有服用方便、不良反应少等特点,是临床治疗FD的一种较佳药物,值得临床推广使用。
Objective： To observe clinical efficacy of low-dose Omeprazole to functional dyspepsia,and analyze its clinical significance.Methods： 52 patients with FD treated in our hospital during March 2010-March 2011 were randomly divided into Omeprazole group and Mosapride group,Omeprazole group received low-dose oral Omeprazole treatment,and Mosapride group were given Mosapride oral treatment.Score of acid reflux,fullness,upper abdominal pain/discomfort points before and after the treatment as well as their clinical efficacy and adverse reactions were observed and compared.Results： Score acid reflux,fullness,upper abdominal pain/discomfort after the treatment were significantly lower than those before the treatment in both groups,which all had significant differences in each group;Score of acid reflux,upper abdominal pain/discomfort of the Omeprazole group after the treatment were significantly lower than those of the Mosapride group,which had significant difference（P0.05）;The effective rate of the Omeprazole group was as high as 94.44%,significantly higher than that of mosapride group,75.60%,which had significant difference（P0.05）;Significant adverse reactions were not found in both two groups.Conclusion： For FD,low dose Omeprazole can significantly improve the stomach burning feeling and abdominal pain and it has positive clinical effect and is easy to take with little adverse reactions,which is a better drug for clinical treatment of FD and worthy of clinical use.
出处
《中国医药导报》
CAS
2011年第16期90-92,共3页
China Medical Herald
关键词
功能性消化不良
奥美拉唑
莫沙必利
反酸
饱胀
上腹痛/不适
Functional dyspepsia
Omeprazole
Mosapride
Anti-acid
Fullness
Upper abdominal pain/discomfort
