摘要
目的：评估鼻用糖皮质激素对变应性鼻炎（AR）患者口鼻呼出气NO浓度的影响,探讨相关的影响因素。方法：测量27例中重度持续性AR患者口、鼻腔呼出气NO浓度及鼻部症状（鼻塞、鼻痒、打喷嚏、流清涕）视觉模拟评分（VAS）,同时使用鼻-结膜炎相关生活质量问卷（RQLQ）评估患者生活质量。经鼻用糖皮质激素（糠酸莫米松鼻喷雾剂,200μg/d,每日1次）治疗2周后重复测量,对比测量指标的变化情况。结果：治疗前,患者口和鼻呼出气NO浓度分别为20（18－44）×10-9和（960±298）×10-9;治疗后,口呼出气NO浓度为24（17－35）×10-9,与治疗前相比无明显改变;鼻呼出气NO浓度降至（817±188）×10-9,较治疗前显著下降（P〈0.01）。治疗后患者各项鼻部症状VAS评分以及RQLQ评分均较治疗前显著下降。治疗前后患者口、鼻呼出气NO浓度与各项鼻部症状VAS评分、RQLQ各项评分间均无显著相关性。结论：鼻用糖皮质激素短期治疗中重度持续性AR患者,在显著降低患者鼻腔炎症的同时,能够明显改善各项鼻部症状,提高患者生活质量。
Objective：To evaluate the effects of nasal momestasone furoate on oral and nasal nitric oxide（NO） production in patients with allergic rhinitis.Method：Twenty-seven patients with moderate to severe symptoms of persistent allergic rhinitis were treated with momestasone furoate nasal spray（200 μg / d,qd） for 2 weeks.Nasal and oral exhaled nitric oxide concentrations,symptoms of rhinitis and quality of life were investigated before and after the treatment.Result：There was a significant improvement in nasal exhaled nitric oxide concentrations,symptoms of rhinitis and quality of life,but not in oral exhaled nitric oxide concentrations.Subjective improvements in symptoms and quality of life did not correlate significantly with objective measurements.Conclusion：Our study provides subjective and objective evidence on the efficacy of intranasal momestasone furoate in improving nasal symptoms and quality of life,as well as reducing nasal inflammation.
出处
《临床耳鼻咽喉头颈外科杂志》
CAS
CSCD
北大核心
2011年第20期913-915,919,共4页
Journal of Clinical Otorhinolaryngology Head And Neck Surgery
基金
国家杰出青年科学基金(No:81025007)
国家自然科学基金项目(No:30872846
30973282)
北京市自然基金(No:7102030)
北京市教委科技计划重点项目(No:KZ200910025008)
