摘要
目的:探讨睾丸生殖细胞肿瘤的诊断、治疗、预后情况及对性功能的影响。方法:对1 992年3月～2006年4月收住院的睾丸生殖细胞肿瘤患者的临床及随访资料进行回顾性分析和总结。结果:精原细胞瘤(SGCT)患者平均发病年龄40.3岁,比非精原细胞瘤(NSGCT)大6.9岁;B超显示,SGCT多表现为低回声,NSGCT多为不均匀回声;两者5年总生存率分别为93.94%、82.35%;疾病或治疗相关性性功能障碍发生率14.29%。结论:①血清肿瘤标志物、超声、腹部CT检查对于睾丸生殖细胞肿瘤的诊断、临床分期及顶后判断有一定参考价值。②SGCTⅠ期患者单纯手术与手术加放疗疗效相当,Ⅱ期患者应给予手术加放疗;NSGCT患者应给予手术加化疗等综合治疗。③睾丸肿瘤及相关治疗对性功能影响较小,勃起功能障碍主要与放疗有关。
Objective.. To investigate the diagnosis,treatment and prognosis of testicular germ cell tumor and evaluate its effects on sexual function. Method：A total of 62 patients with testicular germ cell tumor treated at the Department of Urology,2nd Hospital of Tianjin Medical University from Mar. 1992 to Apr. 2006 were reviewed. Clinical information as well as follow up data were retrospectively summarized and analyzed. Result：The mean age of onset for testicular semino- ma is 40.3,which is 6.9 years later than non-seminoma. Ultrasonography indicated that seminoma appears low-level echo while the non-seminoma mixed ones. The overall 5-year survival rates of seminoma and non-seminoma were 93.94 % and 82.35%, respectively. Moreover, the incidence of sexual dysfunction related to testicular tumor or induced by therapy was 14.29%. Conclusion.. The serum tumor markers, ultrasonography as well as abdominal computed tomography （CT） offer refered values for diagnosis, clinical staging and prognosis of testicular germ cell tumor. For stage Iseminoma, compared to orchidectomy-only group, no advancement in 5-year survival rate was observed in ones treated by orchidectomy and radiation therapy （RT）. Both orchidectomy and RT are necessary to stage Ⅱ seminoma. The treatment modalities of non-semi- noma should include orchidectomy and chemotherapy. No significant adverse effect was found on sexual function attributed to testicular tumor or therapy. Erectile dysfunction was caused by RT.
出处
《临床泌尿外科杂志》
北大核心
2011年第10期772-774,共3页
Journal of Clinical Urology
关键词
睾丸
生殖细胞肿瘤
放疗
化疗
性功能
testis
germ cell tumor
radiation therapy
chemotherapy
sexual function
